| Differential influence of butyrate concentration on proximal and distal colonic mucosa in rats born germ-free and associated with a strain of Clostridium paraputrificum. | |
| | |
MedLine Citation:
|
PMID: 11223399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In vivo influence of butyrate in colonic mucosa was studied using a model of gnotobiotic rats monoassociated with a Clostridium paraputrificum. Rats were fed a diet containing increasing amounts of non-digestible carbohydrates, the fermentation of which led to modulated amounts of butyrate in the large intestine. In the proximal colon, the increase in the butyrate concentration alters crypt depth and the number of mucus-containing cells; the increase in butyrate was highly correlated with the number of neutral-mucin-containing cells. Conversely, in the distal colon, no relation was found between the increase in butyrate concentration and crypt depth or number of mucin-containing cells. In both the proximal and distal colon, the mitotic index remained unchanged. In conclusion, in vivo production of physiological quantities of butyrate had a trophic effect on proximal colonic mucosa, but did not influence the distal epithelium. |
| | |
Authors:
|
J C Meslin; M Bensaada; F Popot; C Andrieux |
Related Documents
:
|
10710539 - Asymmetrical targeting of type ii na-p(i) cotransporters in renal and intestinal epithe... 2530809 - Glycosylation in human colorectal mucosa during tumor development studied by lectins. 20126989 - Reg4 acts as a mitogenic, motility and pro-invasive factor for colon cancer cells. 8692869 - Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin. 11976909 - Vimentin-positive cells in the villus epithelium of the rabbit small intestine. 6808569 - Control mechanisms of crypt cell production in the small intestinal epithelium. 1068469 - Correlation between tumor induction and the large external transformation sensitive pro... 7054309 - Effect of lipids on the aggregation and permeability of human stratum corneum. 2002799 - Premature onset of mitosis and potentiation of chromosome damage induced by poly-d-lysi... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Volume: 128 ISSN: 1095-6433 ISO Abbreviation: Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Publication Date: 2001 Feb |
Date Detail:
|
Created Date: 2001-03-06 Completed Date: 2001-05-17 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9806096 Medline TA: Comp Biochem Physiol A Mol Integr Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: 379-84 Citation Subset: IM |
Affiliation:
|
Laboratoire d'Ecologie et de Physiologie du Système Digestif, Unité Métabolites Bactériens et Santé, Domaine de Vilvert, 78352 Cedex, Jouy-en-Josas, France. meslin@jouy.inra.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Butyrates / pharmacology* Clostridium / isolation & purification* Colon / drug effects*, microbiology Germ-Free Life Intestinal Mucosa / drug effects*, metabolism Male Rats Rats, Inbred F344 |
| Chemical | |
Reg. No./Substance:
|
0/Butyrates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of hypergravity on the Ca/Sr composition of developing otoliths of larval cichlid fish (Oreoc...
Next Document: Compartmental responses to acute osmotic stress in Leishmania major result in rapid loss of Na+ and ...