Document Detail


Differential induction of cytochrome P450-mediated triasulfuron metabolism by naphthalic anhydride and triasulfuron.
MedLine Citation:
PMID:  8539299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytochrome P450 monooxygenases play paramount roles in the detoxification of herbicides as well as in the synthesis of lignins, flavonoids, and phenolic acids. Biochemical analysis of triasulfuron metabolism in maize (Zea mays) seedlings has demonstrated that the P450(s) responsible for detoxification of this herbicide is induced by naphthalic anhydride (NA), a plant safener, and by triasulfuron, the herbicide itself. Induction studies conducted with seedlings of different ages suggest that two separate response pathways modulate this P-450 activity. Induction by NA is independent of the developmental age of the seedlings up to 6.5 d; induction by triasulfuron is tightly modulated with respect to developmental age in that triasulfuron metabolism can be induced by triasulfuron in young (2.5 d) but not older (6.5 d) seedlings. Induction by NA administered in combination with triasulfuron synergistically enhances triasulfuron metabolism in younger seedlings to levels substantially above that obtained with either herbicide or safener treatment alone. In older seedlings, NA plus triasulfuron treatment induces triasulfuron metabolism to only the level of NA treatment alone, indicating again that the induction cascade responding to triasulfuron is nonfunctional in later development. MnCl2 studies indicate that the triasulfuron insensitivity of older seedlings does not result from a general limitation in the inducibility of this P-450 detoxification system but rather from specific limitations in the triasulfuron-response pathway.
Authors:
M W Persans; M A Schuler
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Plant physiology     Volume:  109     ISSN:  0032-0889     ISO Abbreviation:  Plant Physiol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-02-08     Completed Date:  1996-02-08     Revised Date:  2010-09-10    
Medline Journal Info:
Nlm Unique ID:  0401224     Medline TA:  Plant Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1483-90     Citation Subset:  IM    
Affiliation:
Department of Plant Biology, University of Illinois, Urbana 61801, USA.
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MeSH Terms
Descriptor/Qualifier:
Biotransformation
Cytochrome P-450 Enzyme System / biosynthesis*
Enzyme Induction
Herbicides / metabolism*,  pharmacology*
Metabolic Detoxication, Drug
Microsomes / enzymology
Mixed Function Oxygenases / biosynthesis*
Molecular Structure
Naphthalenes / pharmacology*
Sulfonylurea Compounds / metabolism*,  pharmacology*
Zea mays / metabolism*
Chemical
Reg. No./Substance:
0/Herbicides; 0/Naphthalenes; 0/Sulfonylurea Compounds; 81-84-5/1,8-naphthalenedicarboxylic acid anhydride; 82097-50-5/triasulfuron; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.-/Mixed Function Oxygenases
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