Document Detail

Differential induction by interferons of major histocompatibility complex-encoded and non-major histocompatibility complex-encoded antigens in human breast and ovarian carcinoma cell lines.
MedLine Citation:
PMID:  2497969     Owner:  NLM     Status:  MEDLINE    
Treatment of cancer cells with interferons can modulate expression of cell surface antigens, particularly those of the major histocompatibility complex (MHC). To examine the effect of recombinant gamma- and alpha-interferons on expression of non-MHC antigens, murine monoclonal antibodies have been used to quantitate 14 distinct tumor-associated cell surface antigens from five breast cancer cell lines and five ovarian cancer cell lines using a live cell radioimmunoassay. Both Class I and Class II MHC antigens could be augmented or induced with gamma-interferon. Significantly increased expression of MHC antigens was observed in nine of 10 cell lines with induction indices as high as 11-fold. When 17 non-MHC epitopes were measured on 10 cell lines, minimal (1.3-2.7-fold) induction was observed in 10 of the 170 instances evaluated. Expression of only two epitopes, 2G3 and 735B11, was increased on more than one cell line. On six cell lines expression of non-MHC epitopes could not be increased. Consequently, among many different cell surface determinants, interferons produced a highly selective augmentation or induction of MHC antigens, whereas augmentation or induction of other tumor-associated antigens was apparently restricted to a few epitopes.
C M Boyer; D V Dawson; S E Neal; L F Winchell; D S Leslie; D Ring; R C Bast
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  49     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-06-23     Completed Date:  1989-06-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2928-34     Citation Subset:  IM    
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
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MeSH Terms
Antigens, Neoplasm / metabolism*
Antigens, Surface / metabolism*
Breast Neoplasms / immunology*
Cell Division / drug effects
Genes, MHC Class I
Interferon Type I / pharmacology*
Interferon-gamma / pharmacology*
Major Histocompatibility Complex*
Molecular Weight
Ovarian Neoplasms / immunology*
Tumor Cells, Cultured / immunology
Grant Support
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Antigens, Surface; 0/Interferon Type I; 82115-62-6/Interferon-gamma

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