| Differential indication of lipoprotein apheresis during pregnancy. | |
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MedLine Citation:
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PMID: 12924613 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lipoprotein apheresis is an effective treatment for severe disorders of lipid metabolism. It is the only life prolonging therapy for patients with homozygous familial hypercholesterolemia. Changes of lipid metabolism during pregnancy related to changes of hormone concentrations do not cause clinical complications in the majority of cases. However, in particular clinical situations there is the need to offer a therapeutic option. Increasing morbidity and mortality of mother and child due to severe disorders of lipid metabolism have to be prevented. In general, lipid lowering drugs are contraindicated during pregnancy. Therefore, lipoprotein apheresis offers an alternative, which could be used in select cases to treat acute or chronic hyperlipoproteinemia associated with pregnancy. This article summarizes experiences with patients, who became pregnant during chronic lipoprotein apheresis, or who were treated by lipoprotein apheresis because of acute disorders of lipid metabolism during pregnancy. In conclusion, after individual risk benefit analysis for mother and child lipoprotein apheresis can be safely performed during pregnancy. |
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Authors:
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Reinhard Klingel; Britta Göhlen; Andreas Schwarting; Frido Himmelsbach; Richard Straube |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Volume: 7 ISSN: 1744-9979 ISO Abbreviation: Ther Apher Dial Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-08-19 Completed Date: 2004-02-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101181252 Medline TA: Ther Apher Dial Country: Australia |
Other Details:
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Languages: eng Pagination: 359-64 Citation Subset: IM |
Affiliation:
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Apheresis Research Institute, Cologne, Germany. afi@apheresis-research.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Component Removal
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methods Cholesterol, LDL / blood*, metabolism Female Follow-Up Studies Humans Hyperlipoproteinemia Type II / diagnosis, therapy* Lipid Metabolism Lipoproteins, LDL / blood*, metabolism Plasmapheresis / adverse effects, methods* Pregnancy Pregnancy Complications / diagnosis, therapy* Pregnancy Outcome Pregnancy, High-Risk Risk Assessment Severity of Illness Index Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL; 0/Lipoproteins, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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