| Differential increase in cerebrospinal fluid-acetylcholinesterase after treatment with acetylcholinesterase inhibitors in patients with Alzheimer's disease. | |
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MedLine Citation:
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PMID: 11226635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The clinical significance and the effects of pharmacological treatment of patients with Alzheimer's disease (AD) were evaluated by measurement of acetylcholinesterase (AChE) in the cerebrospinal fluid (CSF). CSF-AChE of AD patients was lower, not significantly, compared with controls. However, CSF-AChE was significantly increased after treatment of AD patients with AChE inhibitors (donepezil and galantamine). The increase was higher in patients treated with donezepil than in those treated with galantamine, which might be related to different mechanisms for the substances. The increase was also dose-dependent, and was especially marked in patients showing a clinical response. These data suggest that CSF biomarkers are capable not only of identifying a biochemical effect of drugs, but also of differentiating between different compounds in a dose-dependent manner. |
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Authors:
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P Davidsson; K Blennow; N Andreasen; B Eriksson; L Minthon; C Hesse |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 300 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-03-06 Completed Date: 2001-06-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 157-60 Citation Subset: IM |
Affiliation:
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Department of Clinical Neuroscience, Experimental Neuroscience section, Göteborg University, Sahlgrenska University Hospital, S-431 80, Mölndal, Sweden. pia.davidsson@neuro.gu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholinesterase
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cerebrospinal fluid*,
drug effects* Aged Aged, 80 and over Alzheimer Disease / cerebrospinal fluid*, drug therapy Analysis of Variance Biological Markers / cerebrospinal fluid Cholinesterase Inhibitors / pharmacology*, therapeutic use Dose-Response Relationship, Drug Female Galantamine / pharmacology*, therapeutic use Humans Indans / pharmacology*, therapeutic use Male Middle Aged Piperidines / pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cholinesterase Inhibitors; 0/Indans; 0/Piperidines; 120011-70-3/donepezil; 357-70-0/Galantamine; EC 3.1.1.7/Acetylcholinesterase |
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