Document Detail

Differential in vivo gene expression of major Leptospira proteins in resistant or susceptible animal models.
MedLine Citation:
PMID:  22729538     Owner:  NLM     Status:  MEDLINE    
Transcripts of Leptospira 16S rRNA, FlaB, LigB, LipL21, LipL32, LipL36, LipL41, and OmpL37 were quantified in the blood of susceptible (hamsters) and resistant (mice) animal models of leptospirosis. We first validated adequate reference genes and then evaluated expression patterns in vivo compared to in vitro cultures. LipL32 expression was downregulated in vivo and differentially regulated in resistant and susceptible animals. FlaB expression was also repressed in mice but not in hamsters. In contrast, LigB and OmpL37 were upregulated in vivo. Thus, we demonstrated that a virulent strain of Leptospira differentially adapts its gene expression in the blood of infected animals.
Mariko Matsui; Marie-Estelle Soupé; Jérôme Becam; Cyrille Goarant
Related Documents :
22562198 - The zebrafish sf3b1b460 mutant reveals differential requirements for the sf3b1 pre-mrna...
22753658 - Differential gene expression profiles may differentiate responder and nonresponder pati...
22278178 - Genetic analysis of leaf rust resistance genes and associated markers in the durable re...
22532138 - Characteristics of klebsiella pneumoniae harboring qnrb32, aac(6')-ib-cr, gyra and ctx-...
12086698 - Changes in gene expression during aging in the brown norway rat epididymis.
20338518 - Two alternative starter modules for the non-ribosomal biosynthesis of specific anabaeno...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-22
Journal Detail:
Title:  Applied and environmental microbiology     Volume:  78     ISSN:  1098-5336     ISO Abbreviation:  Appl. Environ. Microbiol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-10     Completed Date:  2012-12-11     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  7605801     Medline TA:  Appl Environ Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6372-6     Citation Subset:  IM    
Institut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, Bacterial Research Laboratory, Noumea, New Caledonia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bacterial Proteins / biosynthesis*
Blood / microbiology
Disease Models, Animal
Disease Resistance
Gene Expression Profiling
Gene Expression Regulation, Bacterial*
Host-Pathogen Interactions
Leptospira / genetics*
Leptospirosis / microbiology*
RNA, Ribosomal, 16S / biosynthesis
Reg. No./Substance:
0/Bacterial Proteins; 0/RNA, Ribosomal, 16S

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Accumulation of intracellular glycogen and trehalose by Propionibacterium freudenreichii under condi...
Next Document:  Firing range soils yield a diverse array of fungal isolates capable of organic acid production and P...