Document Detail


Differential in situ expression of IL-17 in skin diseases.
MedLine Citation:
PMID:  23211678     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Interleukin (IL)-17 is a key molecule for epithelial immunity and inflammation. Objectives: To quantify IL-17 expression in situ in a large panel of cutaneous diseases. 289 samples of the 30 most common cutaneous infectious, autoimmune, inflammatory and tumor diseases were stained for IL-17 immunohistochemically. IL-17 expression strongly varied between the diseases, but was conserved within each disease. The major cellular sources of IL-17 were T cells and granulocytes. Skin diseases caused by extracellular microbials were infiltrated by many IL-17+ cells, while intracellular infections were scarcely positive for IL-17. While autoimmune diseases were mostly accompanied by IL-17+ T cells, IL-17+ granulocytes were dominant in neutrophilic dermatoses. Cutaneous diseases show a characteristic pattern of IL-17+ cellular infiltrate. These patterns are relevant for the clinician, since therapeutic approaches targeting differentiation of Th17 cells as well as direct targeting of IL-17 are or will become available.
Authors:
Mattias Fischer-Stabauer; Alexander Boehner; Stefanie Eyerich; Teresa Carbone; Claudia Traidl-Hoffmann; Carsten B Schmidt-Weber; Andrea Cavani; Johannes Ring; Ruediger Hein; Kilian Eyerich
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-5
Journal Detail:
Title:  European journal of dermatology : EJD     Volume:  -     ISSN:  1952-4013     ISO Abbreviation:  Eur J Dermatol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9206420     Medline TA:  Eur J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Dermatology and Allergy.
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