Document Detail

Differential in situ expression of IL-17 in skin diseases.
MedLine Citation:
PMID:  23211678     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To quantify IL-17 expression in situ in a large panel of cutaneous diseases. 289 samples of the 30 most common cutaneous infectious, autoimmune, inflammatory and tumor diseases were stained for IL-17 immunohistochemically. IL-17 expression strongly varied between the diseases, but was conserved within each disease. The major cellular sources of IL-17 were T cells and granulocytes. Skin diseases caused by extracellular microbials were infiltrated by many IL-17+ cells, while intracellular infections were scarcely positive for IL-17. While autoimmune diseases were mostly accompanied by IL-17+ T cells, IL-17+ granulocytes were dominant in neutrophilic dermatoses. Cutaneous diseases show a characteristic pattern of IL-17+ cellular infiltrate. These patterns are relevant for the clinician, since therapeutic approaches targeting differentiation of Th17 cells as well as direct targeting of IL-17 are or will become available.
Mattias Fischer-Stabauer; Alexander Boehner; Stefanie Eyerich; Teresa Carbone; Claudia Traidl-Hoffmann; Carsten B Schmidt-Weber; Andrea Cavani; Johannes Ring; Ruediger Hein; Kilian Eyerich
Related Documents :
21108588 - 10th world conference of the world organization for specialized studies on diseases of ...
23424598 - Adult onset still's disease: a case report with a rare clinical manifestation and patho...
23030328 - Infections associated with chronic granulomatous disease: linking genetics to phenotypi...
23874838 - Oral neutrophil transcriptome changes result in a pro-survival phenotype in periodontal...
6952838 - Alcohol unrelated hepato-biliary disorders in the alcoholic: the role of liver biopsy i...
22858658 - Rare manifestation of acute pulmonary edema associated with acute lupus myocarditis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of dermatology : EJD     Volume:  22     ISSN:  1952-4013     ISO Abbreviation:  Eur J Dermatol     Publication Date:    2012 Nov-Dec
Date Detail:
Created Date:  2012-12-31     Completed Date:  2013-06-19     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9206420     Medline TA:  Eur J Dermatol     Country:  France    
Other Details:
Languages:  eng     Pagination:  781-4     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Eosinophils / metabolism
Interleukin-17 / metabolism*
Lymphocyte Count
Neutrophils / metabolism
Skin Diseases / immunology*,  metabolism*,  pathology
Th17 Cells / metabolism*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Toxicopathological evaluation in Wistar rats (Rattus norvegicus) following repeated oral exposure to...
Next Document:  Comparative functional properties of two structurally similar selective nonpeptide drug-like ligands...