| Differential improvements in lipid profiles and framingham recurrent risk score in patients with and without diabetes mellitus undergoing long-term cardiac rehabilitation. | |
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MedLine Citation:
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PMID: 21878208 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether lipid profiles and recurrent coronary heart disease (CHD) risk could be modified in patients with and without diabetes mellitus undergoing long-term cardiac rehabilitation (CR). DESIGN: Retrospective analysis of patient case records. SETTING: Community-based phase 4 CR program. PARTICIPANTS: Patients without diabetes (n=154; 89% men; mean ± SD age, 59.6±8.5y; body mass index [BMI], 27.0±3.5kg/m(2)) and patients with diabetes (n=20; 81% men; mean age, 63.0±8.7y; BMI, 28.7±3.3kg/m(2)) who completed 15 months of CR. INTERVENTIONS: Exercise testing and training, risk profiling, and risk-factor education. MAIN OUTCOME MEASURES: Cardiometabolic risk factors and 2- to 4-year Framingham recurrent CHD risk scores were assessed. RESULTS: At follow up, a significant main effect for time was evident for decreased body mass and waist circumference and improved low-density lipoprotein cholesterol (LDL-C) level and submaximal cardiorespiratory fitness (all P<.05), showing the benefits of CR in both groups. However, a significant group-by-time interaction effect was evident for high-density lipoprotein cholesterol (HDL-C) level and total cholesterol (TC)/HDL-C ratio (both P<.05). TC/HDL-C ratio improved (5.0±1.5 to 4.4±1.3) in patients without diabetes, but showed no improvement in patients with diabetes (4.8±1.6 v 4.9±1.6). CONCLUSIONS: We showed that numerous anthropometric, submaximal fitness, and cardiometabolic risk variables (especially LDL-C level) improved significantly after long-term CR. However, some aspects of cardiometabolic risk (measures incorporating TC and HDL-C) improved significantly in only the nondiabetic group. |
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Authors:
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Sean Carroll; Costas Tsakirides; James Hobkirk; James W A Moxon; James W D Moxon; Michael Dudfield; Lee Ingle |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of physical medicine and rehabilitation Volume: 92 ISSN: 1532-821X ISO Abbreviation: Arch Phys Med Rehabil Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985158R Medline TA: Arch Phys Med Rehabil Country: United States |
Other Details:
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Languages: eng Pagination: 1382-7 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Leeds Metropolitan University, Leeds, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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