Document Detail

Differential immunoreactivity of her-2/neu oncoprotein in prostatic tissues.
MedLine Citation:
PMID:  1285216     Owner:  NLM     Status:  MEDLINE    
To investigate HER-2/neu oncoprotein immunoreactivity, monoclonal antibody TA1 immunohistochemical examination of flash-frozen radical prostatectomy specimens was performed (n = 35). All prostatic specimens contained benign prostatic hyperplasia (BPH) and/or prostatic intraepithelial neoplasia (PIN), as well as prostatic carcinoma (CaP). HER-2/neu oncoprotein immunoreactivity in BPH tissues was not significantly different than that for the PIN basal cell layer (P = 0.10) or for the PIN luminal cells (P = 0.17). There was significantly more HER-2/neu oncoprotein immunoreactivity in BPH than in areas of CaP (P < 0.001). There was no significant difference in the amount of immunoreactivity present in PIN basal cells when compared to the PIN luminal cells (P = 0.49). Both the PIN basal cells and luminal cells stained for the HER-2/neu oncoprotein to a higher degree than cells in the CaP areas (P < 0.001 in both cases). HER-2/neu oncoprotein immunoreactivity is present at a significantly higher degree in BPH and PIN than in malignant prostatic epithelium.
G K Ibrahim; J A MacDonald; B J Kerns; S N Ibrahim; P A Humphrey; C N Robertson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Surgical oncology     Volume:  1     ISSN:  0960-7404     ISO Abbreviation:  Surg Oncol     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1994-01-13     Completed Date:  1994-01-13     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9208188     Medline TA:  Surg Oncol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  151-5     Citation Subset:  IM    
Division of Urology, Duke University Medical Center, Durham, NC 27710.
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MeSH Terms
Carcinoma / metabolism
Immunoenzyme Techniques
Middle Aged
Oncogene Proteins, Viral / metabolism*
Prostate / metabolism*
Prostatic Hyperplasia / metabolism
Prostatic Neoplasms / metabolism
Receptor, erbB-2
Reg. No./Substance:
0/Oncogene Proteins, Viral; EC, erbB-2

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