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Differential hippo signaling in early mouse embryos.
MedLine Citation:
PMID:  21411395     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Preimplantation mouse embryos form two types of cells by the blastocyst stage: trophectoderm (TE) and inner cell mass (ICM). In spite of this being the earliest lineage specified in mammalian embryos, few critical molecular mechanisms had been elucidated to distinguish between two historical models: the inside-outside model and the polarity model. In this study, the authors beautifully showed that differential Hippo signaling along the inside-outside axis of the embryo regulates the binary cell-fate switch by modulating activity of the transcription factor Tead4. Tead4 activity is active in outside cells and promotes TE development, whereas it is suppressed in inside cells by cell contact- and phosphorylation-mediated inhibition of nuclear localization of the Tead4 coactivator protein Yap. In terms of techniques employed, it is fun to know that the authors took full advantage of various tools of molecular biology, embryology, genetics, and cell biology, such as a classical blocking antibody, to E-cadherin. Now the authors' ambitious goal is to integrate the molecular mechanism regulated by the Hippo pathway with the two historical models. This PaperPick refers to "The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass" by N. Nishioka, K. Inoue, K. Adachi, H. Kiyonari, M. Ota, A. Ralston, N. Yabuta, S. Hirahara, R.O. Stephenson, N. Ogonuki, R. Makita, H. Kurihara, E.M. Morin-Kensicki, H. Nojima, J. Rossant, K. Nakao, H. Niwa, and H. Sasaki, published in March 2009. VIDEO ABSTRACT:
Authors:
Tadashi Uemura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental cell     Volume:  20     ISSN:  1878-1551     ISO Abbreviation:  Dev. Cell     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e3     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Graduate School of Biostudies, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8507, Japan.
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