| Differential healing responses in polymer- and nonpolymer-based sirolimus-eluting stents. | |
| | |
MedLine Citation:
|
PMID: 19463356 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: We compared the healing and inflammatory responses of polymer-free bare-metal stents (BMS), polymer-free sirolimus-eluting stents (SES) and polymer-free sirolimus-eluting stents plus estradiol (SES+ED) to Cypher drug-eluting stents (CDES) in a rabbit model of overlapping stent placement. BACKGROUND: Inflammatory responses to polymers and delayed healing remain important safety issues associated with CDES. Whether nonpolymeric stents that elute sirolimus or sirolimus and estradiol provoke less inflammation and heal better is unknown. METHODS: Twenty-eight rabbits received 2 overlapping stents in each iliac artery: SES, SES+ED, BMS, or CDES, and vessels were harvested at 28 days for histology and scanning electron microscopy. RESULTS: Although similar at nonoverlapping segments, neointimal thickness within the overlap site of CDES was significantly less than in SES, SES+ED, and BMS (0.07 +/- 0.04 mm vs. 0.16 +/- 0.03 mm, 0.14 +/- 0.03 mm, and 0.15 +/- 0.03 mm, p < 0.0001). Endothelialization was greater in SES, SES+ED, and BMS compared with CDES in nonoverlapping sections (80.0 +/- 5.0% vs. 95.3 +/- 5.0%, 97.5 +/- 2.5%, and 96.7 +/- 3.8%; p = 0.0028) and overlapping sections (85.8 +/- 2.9% vs. 90.8 +/- 6.3%, 89.2 +/- 6.3%, and 48.3 +/- 2.9%; p < 0.0001). The number of luminal eosinophils was also less in overlapping sections of SES, SES+ED, and BMS versus CDES but was similar in nonoverlapping sections. CONCLUSIONS: Polymer-free stents coated with SES or SES+ED result in less robust neointimal suppression but markedly improved arterial healing compared with CDES in the rabbit model. |
| | |
Authors:
|
Michael C John; Rainer Wessely; Adnan Kastrati; Albert Schömig; Michael Joner; Mayu Uchihashi; Johanna Crimins; Scott Lajoie; Frank D Kolodgie; Herman K Gold; Renu Virmani; Aloke V Finn |
Related Documents
:
|
10556406 - Duplex ultrasonography in assessing restenosis of renal artery stents. 8044966 - Transcatheter delivery of c-myc antisense oligomers reduces neointimal formation in a p... 19898936 - A novel simulation strategy for stent insertion and deployment in curved coronary bifur... 12909076 - Contrast media as carriers for local drug delivery. successful inhibition of neointimal... 20868856 - Off-pump kawashima operation. 7637116 - Pancreaticoduodenal artery aneurysm: a case report and review of the literature. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: JACC. Cardiovascular interventions Volume: 1 ISSN: 1876-7605 ISO Abbreviation: JACC Cardiovasc Interv Publication Date: 2008 Oct |
Date Detail:
|
Created Date: 2009-05-25 Completed Date: 2009-06-11 Revised Date: 2012-08-29 |
Medline Journal Info:
|
Nlm Unique ID: 101467004 Medline TA: JACC Cardiovasc Interv Country: United States |
Other Details:
|
Languages: eng Pagination: 535-44 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Massachusetts General Hospital, Boston, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angioplasty, Balloon
/
adverse effects,
instrumentation* Animals Cardiovascular Agents / administration & dosage* Cytokines / metabolism Drug-Eluting Stents* Fibrinolytic Agents / therapeutic use Iliac Artery / drug effects*, injuries, metabolism, ultrastructure Inflammation / etiology, metabolism, pathology, prevention & control* Intercellular Signaling Peptides and Proteins / metabolism Metals Microscopy, Electron, Scanning Models, Animal Organ Culture Techniques Polymers* Prosthesis Design Rabbits Sirolimus / administration & dosage* Stents* Wound Healing / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Cardiovascular Agents; 0/Cytokines; 0/Fibrinolytic Agents; 0/Intercellular Signaling Peptides and Proteins; 0/Metals; 0/Polymers; 53123-88-9/Sirolimus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A randomized, controlled, multicenter trial to evaluate the safety and efficacy of zotarolimus- vers...
Next Document: Preliminary results of the hydroxyapatite nonpolymer-based sirolimus-eluting stent for the treatment...