Document Detail


Differential growth inhibition of human diploid fibroblasts by 2-deoxyglucose and antimycin A with ageing in vitro.
MedLine Citation:
PMID:  3220259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relative growth inhibitory effects of 2-deoxyglucose and antimycin A were monitored at five stages during the life-span in vitro of human diploid fibroblasts. A marked age-dependent response was observed with 2-deoxyglucose but not with antimycin A. The results confirm an increase in the rate of glycolysis with ageing, which appears to be independent of cellular mitochondrial respiratory chain capacity. This may be associated with reduced utilization of the hexose monophosphate shunt and a consequent decline in the availability of ribose moieties for nucleic acid biosynthesis.
Authors:
A H Bittles; H Baum; N J Monks
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gerontology     Volume:  34     ISSN:  0304-324X     ISO Abbreviation:  Gerontology     Publication Date:  1988  
Date Detail:
Created Date:  1989-03-23     Completed Date:  1989-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7601655     Medline TA:  Gerontology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  236-41     Citation Subset:  IM    
Affiliation:
Department of Anatomy, King's College London, UK.
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MeSH Terms
Descriptor/Qualifier:
Antimycin A / pharmacology*
Cell Division / drug effects
Cell Survival
Deoxy Sugars / pharmacology*
Deoxyglucose / pharmacology*
Fibroblasts / cytology*
Glycolysis
Humans
Chemical
Reg. No./Substance:
0/Deoxy Sugars; 154-17-6/Deoxyglucose; 642-15-9/Antimycin A

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