Document Detail


Differential growth inhibition of human diploid fibroblasts by 2-deoxyglucose and antimycin A with ageing in vitro.
MedLine Citation:
PMID:  3220259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relative growth inhibitory effects of 2-deoxyglucose and antimycin A were monitored at five stages during the life-span in vitro of human diploid fibroblasts. A marked age-dependent response was observed with 2-deoxyglucose but not with antimycin A. The results confirm an increase in the rate of glycolysis with ageing, which appears to be independent of cellular mitochondrial respiratory chain capacity. This may be associated with reduced utilization of the hexose monophosphate shunt and a consequent decline in the availability of ribose moieties for nucleic acid biosynthesis.
Authors:
A H Bittles; H Baum; N J Monks
Related Documents :
24246889 - Sex expression and reproductive biology in a tree species, fraxinus excelsior l.
24110829 - Use of an ultra-miniaturized imu-based motion capture system for objective evaluation a...
20445089 - Colloquium paper: how grandmother effects plus individual variation in frailty shape fe...
21658069 - Pubertal development timing in urban chinese boys.
14527839 - Age- and sex-dependent distribution of persistent organochlorine pollutants in urban fo...
6207079 - The effect of age on the microheterogeneous pattern of human myelin basic protein.
2205629 - Secondary hypogonadism in older men: its relation to impotence.
12713029 - Age-related changes of element contents in human tendon of the iliopsoas muscle and the...
3232329 - The effects of fixation of the ulna to the radius in young foals.
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gerontology     Volume:  34     ISSN:  0304-324X     ISO Abbreviation:  Gerontology     Publication Date:  1988  
Date Detail:
Created Date:  1989-03-23     Completed Date:  1989-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7601655     Medline TA:  Gerontology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  236-41     Citation Subset:  IM    
Affiliation:
Department of Anatomy, King's College London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antimycin A / pharmacology*
Cell Division / drug effects
Cell Survival
Deoxy Sugars / pharmacology*
Deoxyglucose / pharmacology*
Fibroblasts / cytology*
Glycolysis
Humans
Chemical
Reg. No./Substance:
0/Deoxy Sugars; 154-17-6/Deoxyglucose; 642-15-9/Antimycin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of ageing on the nerve fibre population of rat optic nerve.
Next Document:  Effects of long-term Hydergine administration on lipofuscin accumulation in senescent rat brain.