Document Detail


Differential expression of vascular endothelial growth factor isoforms and receptor subtypes in the infarcted heart.
MedLine Citation:
PMID:  22818386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: The vascular endothelial growth factor (VEGF) family contains four major isoforms and three receptor subtypes. The expressions of each VEGF isoform and receptor subtype in cardiac repair/remodeling after myocardial infarction (MI) remain uncertain and are investigated in the current study.
METHODS AND RESULTS: Temporal and spatial expressions of VEGF isoforms and VEGFR subtypes were examined in the infarcted rat heart. Sham-operated rats served as controls. We found that the normal myocardium expressed all VEGF isoforms. Following MI, VEGF-A was only increased in the border zone at day 1 and was significantly decreased in the infarcted heart during the 42 day observation period afterwards. VEGF-B was significantly suppressed in the infarcted heart. VEGF-C and VEGF-D were markedly increased in the infarcted heart in both early and late stages of MI. VEGFR-1 and 2 were significantly decreased in the infarcted heart, while VEGFR-3 was significantly increased, which was primarily expressed in blood vessels and myofibroblasts (myoFb).
CONCLUSIONS: VEGF isoforms and VEGFR subtypes are differentially expressed in the infarcted heart. Increased VEGF-A in the very early stage of MI suggests the potential role in initiating the cardiac angiogenic response. Suppressed cardiac VEGF-B postMI suggests that it may not be critical to cardiac repair. The presence of enhanced VEGF-C and VEGF-D along with its receptor, VEGFR-3, in various cell types of the infarcted heart suggest that these isoforms may regulate multiple responses during cardiac repair/remodeling.
Authors:
Tieqiang Zhao; Wenyuan Zhao; Yuanjian Chen; Li Liu; Robert A Ahokas; Yao Sun
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-19
Journal Detail:
Title:  International journal of cardiology     Volume:  167     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-09-04     Completed Date:  2014-04-22     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2638-45     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Gene Expression Regulation*
Male
Myocardial Infarction / metabolism*,  pathology
Protein Isoforms / biosynthesis
Rats
Rats, Sprague-Dawley
Receptors, Vascular Endothelial Growth Factor / biosynthesis
Vascular Endothelial Growth Factor A / biosynthesis
Vascular Endothelial Growth Factor C / biosynthesis*
Vascular Endothelial Growth Factor D / biosynthesis*
Vascular Endothelial Growth Factor Receptor-3 / biosynthesis*
Grant Support
ID/Acronym/Agency:
1R01-HL096503/HL/NHLBI NIH HHS; R01 HL096503/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Protein Isoforms; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factor C; 0/Vascular Endothelial Growth Factor D; 0/vascular endothelial growth factor A, rat; EC 2.7.10.1/Receptors, Vascular Endothelial Growth Factor; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-3

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