Document Detail

Differential expression of two msh-related homeobox genes Chox-7 and Chox-8 during chick limb development.
MedLine Citation:
PMID:  1346246     Owner:  NLM     Status:  MEDLINE    
We have isolated two closely related cDNAs, Chox-7 and Chox-8, encoding homeodomain-containing proteins homologous to Drosophila msh. The Chox-7 and Chox-8 genes are chicken cognates of mouse Hox-7.1 and Hox-8.1, respectively. In situ hybridization using 3' regions of the cDNAs as probes revealed that the Chox-7 gene is highly expressed in the mesenchyme subjacent to the apical ectodermal ridge whereas Chox-8 expression is localized in the anterodistal mesenchymal region at early stages of limb formation, suggesting different roles during limb development. At later stages, both genes are expressed in the anterior and posterior mesenchymes and in the interdigital mesenchyme where programmed cell death occurs.
T Nohno; S Noji; E Koyama; K Nishikawa; F Myokai; T Saito; S Taniguchi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  182     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-02-18     Completed Date:  1992-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  121-8     Citation Subset:  IM    
Department of Pharmacology, Kawasaki Medical School, Japan.
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MeSH Terms
Amino Acid Sequence
Base Sequence
Chick Embryo
DNA / genetics,  isolation & purification
DNA Probes
Extremities / embryology
Gene Expression Regulation
Gene Library
Genes, Homeobox*
Molecular Sequence Data
Polymerase Chain Reaction
Restriction Mapping
Sequence Homology, Nucleic Acid
Reg. No./Substance:
0/DNA Probes; 0/Oligodeoxyribonucleotides; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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