| Differential expression of lumican and fatty acid binding protein-1: new insights into the histologic spectrum of nonalcoholic fatty liver disease. | |
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MedLine Citation:
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PMID: 19330863 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONCLUSION: Histologically progressive NAFLD is associated with overexpression of lumican, an important mediator of fibrosis in nonhepatic tissues, whereas FABP-1 is paradoxically underexpressed in NASH, suggesting a new potential mechanism of lipotoxicity in NAFLD. Further studies are needed to determine the biologic basis of lumican and/or FABP-1 dysregulation in NAFLD. |
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Authors:
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Michael Charlton; Kimberly Viker; Anuradha Krishnan; Schuyler Sanderson; Bart Veldt; A J Kaalsbeek; Michael Kendrick; Geoffrey Thompson; Florencia Que; James Swain; Michael Sarr |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 49 ISSN: 1527-3350 ISO Abbreviation: Hepatology Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-06 Completed Date: 2009-05-08 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: United States |
Other Details:
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Languages: eng Pagination: 1375-84 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chondroitin Sulfate Proteoglycans / metabolism* Fatty Acid-Binding Proteins / metabolism* Fatty Liver / metabolism*, pathology Female Humans Immunohistochemistry Keratan Sulfate / metabolism* Liver / metabolism*, pathology Male Middle Aged Obesity / metabolism* Polymerase Chain Reaction Proteomics RNA, Messenger / isolation & purification Tandem Mass Spectrometry |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK069757/DK/NIDDK NIH HHS; R01 DK069757-01/DK/NIDDK NIH HHS; R01 DK069757-01/DK/NIDDK NIH HHS; R01 DK069757-04/DK/NIDDK NIH HHS; RR00585/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chondroitin Sulfate Proteoglycans; 0/FABP1 protein, human; 0/Fatty Acid-Binding Proteins; 0/RNA, Messenger; 0/lumican; 9056-36-4/Keratan Sulfate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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