Document Detail


Differential expression of lumican and fatty acid binding protein-1: new insights into the histologic spectrum of nonalcoholic fatty liver disease.
MedLine Citation:
PMID:  19330863     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Histologically progressive NAFLD is associated with overexpression of lumican, an important mediator of fibrosis in nonhepatic tissues, whereas FABP-1 is paradoxically underexpressed in NASH, suggesting a new potential mechanism of lipotoxicity in NAFLD. Further studies are needed to determine the biologic basis of lumican and/or FABP-1 dysregulation in NAFLD.
Authors:
Michael Charlton; Kimberly Viker; Anuradha Krishnan; Schuyler Sanderson; Bart Veldt; A J Kaalsbeek; Michael Kendrick; Geoffrey Thompson; Florencia Que; James Swain; Michael Sarr
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  49     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-06     Completed Date:  2009-05-08     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1375-84     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chondroitin Sulfate Proteoglycans / metabolism*
Fatty Acid-Binding Proteins / metabolism*
Fatty Liver / metabolism*,  pathology
Female
Humans
Immunohistochemistry
Keratan Sulfate / metabolism*
Liver / metabolism*,  pathology
Male
Middle Aged
Obesity / metabolism*
Polymerase Chain Reaction
Proteomics
RNA, Messenger / isolation & purification
Tandem Mass Spectrometry
Grant Support
ID/Acronym/Agency:
R01 DK069757/DK/NIDDK NIH HHS; R01 DK069757-01/DK/NIDDK NIH HHS; R01 DK069757-01/DK/NIDDK NIH HHS; R01 DK069757-04/DK/NIDDK NIH HHS; RR00585/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Chondroitin Sulfate Proteoglycans; 0/FABP1 protein, human; 0/Fatty Acid-Binding Proteins; 0/RNA, Messenger; 0/lumican; 9056-36-4/Keratan Sulfate
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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