| Differential expression of iron metabolism proteins in diabetic and diabetic iron-supplemented rat liver. | |
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MedLine Citation:
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PMID: 22170771 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Diabetes mellitus is associated with altered iron homeostasis that can potentially effect reactive oxygen species generation and contribute to diabetes-related complications. We investigated, by quantitative polymerase chain reaction, whether the expression of liver hepcidin, ferritin, and TfR-1 is altered in diabetes. Rats in the control (C) group received a standard diet; control iron (CI) group received a standard diet supplemented with iron; diabetic (D) group received an injection of streptozotocin; and diabetic iron (DI) group received streptozotocin and the diet with iron. Animals of the D group showed higher levels of serum iron, increased concentration of carbonyl protein, and a decrease in antioxidant status. Group D rats showed increased hepatic expression of Trf-1 compared to the other groups. Iron supplementation reversed this increase. Hepcidin mRNA was 81% higher in DI than in C and CI rats. The results suggest that diabetes, with or without excess iron, can cause perturbations in iron status, hepcidin and Trf-1 expression. © 2011 Wiley Periodicals, Inc. J Biochem Mol Toxicol 00:1-7 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.20418. |
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Authors:
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Maísa Silva; Cintia Lopes de Brito Magalhães; Riva de Paula Oliveira; Marcelo Eustáquio Silva; Maria Lucia Pedrosa |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-14 |
Journal Detail:
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Title: Journal of biochemical and molecular toxicology Volume: - ISSN: 1099-0461 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9717231 Medline TA: J Biochem Mol Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
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Programa de Pós graduação em Ciências Biológicas, Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil. maisasilv@yahoo.com.br. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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