Document Detail


Differential expression of glu-tubulin in relation to mammary gland disease.
MedLine Citation:
PMID:  20697907     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tubulin is one of the molecular components that regulate cytosketal structure relating to cell differentiation, invasion, and metastasis in cancer. Recently, glu-tubulin, in which the C-terminal tyrosine of α-tubulin is removed by tubulin carboxypeptidase, overexpression has been reported in malignant tumors of the mammary gland immunohistochemically. We identified 147 cases accessioned in the Department of Pathology, International University of Health and Welfare Hospital from 2003 to 2009. Of the 78 malignant tumor cases, staining for glu-tubulin was observed in 56 (71.8%), and only 22 cases showed no significant staining. However, in benign disease, glu-tubulin staining was detected in the cytoplasm of fibroblasts and endothelial cells, but was completely absent from epithelial cells in 64 of 69 cases. When the expression of glu-tubulin was compared between malignant tumor, benign tumor, and other benign disease, a significant differentiation was found among expressions of this protein. These results indicate that glu-tubulin represents a strong selective expression for cancer cells and may be useful to identify and quantify human breast cancer.
Authors:
Hajime Kuroda; Ken Saito; Mina Kuroda; Yutaka Suzuki
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Publication Detail:
Type:  Journal Article     Date:  2010-08-10
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  457     ISSN:  1432-2307     ISO Abbreviation:  Virchows Arch.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2010-10-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  477-82     Citation Subset:  IM    
Affiliation:
Department of Pathology, International University of Health and Welfare Hospital, Nasushiobara, Tochigi 329-2763, Japan. hajimek@iuhw.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Breast Diseases / metabolism*,  pathology
Breast Neoplasms / chemistry*,  pathology
Female
Glutamic Acid / analysis*
Humans
Middle Aged
Tubulin / analysis*
Tyrosine / metabolism
Chemical
Reg. No./Substance:
0/Tubulin; 55520-40-6/Tyrosine; 56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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