Document Detail

Differential expression of galectin 3 in solid cell nests and C cells of human thyroid.
MedLine Citation:
PMID:  12560396     Owner:  NLM     Status:  MEDLINE    
AIMS: To provide new insights into characterising solid cell nests and gain information that might help distinguish between solid cell nests and C cells.
METHODS: Thyroid tissue specimens from patients who had undergone prophylactic thyroidectomy for familial medullary thyroid cancer were immunostained for calcitonin, carcinoembryonic antigen, and galectin 3.
RESULTS: Solid cell nests displayed a strong and diffuse staining for carcinoembryonic antigen and galectin 3, but not for calcitonin. C cells located at the periphery of solid cell nests and in neighbouring follicles expressed both calcitonin and carcinoembryonic antigen but not galectin 3. These three markers were positive in medullary thyroid carcinoma.
CONCLUSION: Galectin 3 immunoreactivity permits a better characterisation and differentiation between solid cell nests and C cells, avoiding the misidentification of two biologically and clinically different thyroid structures.
A Faggiano; M Talbot; E Baudin; J M Bidart; M Schlumberger; B Caillou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  56     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-31     Completed Date:  2003-03-25     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  142-3     Citation Subset:  AIM; IM    
Department of Pathology, Institut Gustave Roussy, F-94805 Villejuif Cedex, France.
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MeSH Terms
Calcitonin / metabolism
Carcinoembryonic Antigen / metabolism
Child, Preschool
Galectin 3 / metabolism*
Immunoenzyme Techniques
Neoplasm Proteins / metabolism
Precancerous Conditions / diagnosis*
Thyroid Gland / metabolism
Thyroid Neoplasms / diagnosis*
Tumor Markers, Biological / metabolism*
Reg. No./Substance:
0/Carcinoembryonic Antigen; 0/Galectin 3; 0/Neoplasm Proteins; 0/Tumor Markers, Biological; 9007-12-9/Calcitonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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