| Differential expression of cytochrome P4502E1 (CYP2E1) in Morris hepatomas and livers of tumor bearing rats. | |
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MedLine Citation:
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PMID: 9538127 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this investigation was to determine if the decrease of cytochrome P4502E1 (CYP2E1) in hepatomas is related to the tumor growth rate. There was a significant correlation between N-nitrosodimethylamine (NDMA) demethylase activities and CYP2E1 protein levels in rat liver and hepatomas. The levels of NDMA demethylase activities and CYP2E1 protein content were lower in hepatomas than in the corresponding host livers. NDMA demethylase activities and CYP2E1 protein levels were greater in hepatomas of slow and intermediate growth rate than in fast growing hepatomas. A similar trend was also observed with CYP2E1 mRNA levels. The results demonstrated an inverse relationship between growth rate of rat hepatomas and the expression of CYP2E1. |
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Authors:
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J J Hu; J Y Hong; M A Lea; C S Yang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: International journal of oncology Volume: 12 ISSN: 1019-6439 ISO Abbreviation: Int. J. Oncol. Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-06-02 Completed Date: 1998-06-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9306042 Medline TA: Int J Oncol Country: GREECE |
Other Details:
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Languages: eng Pagination: 1049-53 Citation Subset: IM |
Affiliation:
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Georgetown University Medical Center, Lombardi Cancer Center and Department of Pharmacology, The Research Building, E-316, 3970 Reservoir Rd., Washington, DC 20007, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetone
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pharmacology Animals Cell Division Cytochrome P-450 CYP2E1 / analysis, biosynthesis* DNA Probes Fasting Gene Expression Regulation, Enzymologic / drug effects Gene Expression Regulation, Neoplastic Kinetics Liver Neoplasms, Experimental / enzymology*, pathology* Male Microsomes / enzymology* Microsomes, Liver / enzymology* RNA, Messenger / metabolism Rats Rats, Inbred BUF Reference Values |
| Grant Support | |
ID/Acronym/Agency:
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ES03938/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA Probes; 0/RNA, Messenger; 67-64-1/Acetone; EC 1.14.14.1/Cytochrome P-450 CYP2E1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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