Document Detail

Differential expression of cathepsins K, S and V between young and aged Caucasian women skin epidermis.
MedLine Citation:
PMID:  23871919     Owner:  NLM     Status:  Publisher    
Cutaneous aging translates drastic structural and functional alterations in the extracellular matrix (ECM). Multiple mechanisms are involved, including changes in protease levels. We investigated the age-related protein expression and activity of cysteine cathepsins and the expression of two endogenous protein inhibitors in young and aged Caucasian women skin epidermis. Immunofluorescence studies indicate that the expression of cathepsins K, S and V, as well as cystatins A and M/E within keratinocytes is reduced in photoprotected skin of aged women. Furthermore, the overall endopeptidase activity of cysteine cathepsins in epidermis lysates decreased with age. Albeit dermal elastic fiber and laminin expression is reduced in aged skin, staining of nidogen-1, a key protein in BM assembly that is sensitive to proteolysis by cysteine, metallo- and serine proteases, has a similar pattern in both young and aged skin. Since cathepsins contribute to the hydrolysis and turnover of ECM/basement membrane components, the abnormal protein degradation and deposition during aging process may be related in part to a decline of lysosomal/endosomal cathepsin K, S and V activity.
Juliette Sage; Delphine De Quéral; Emmanuelle Leblanc-Noblesse; Robin Kurfurst; Sylvianne Schnebert; Eric Perrier; Carine Nizard; Gilles Lalmanach; Fabien Lecaille
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-17
Journal Detail:
Title:  Matrix biology : journal of the International Society for Matrix Biology     Volume:  -     ISSN:  1569-1802     ISO Abbreviation:  Matrix Biol.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-7-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9432592     Medline TA:  Matrix Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013.
INSERM, UMR 1100, Pathologies Respiratoires: protéolyse et aérosolthérapie, Centre d'Etude des Pathologies Respiratoires, Université François Rabelais, F-37032 Tours cedex, France; LVMH-Recherche, BP58, F-45800 Saint Jean de Braye, France.
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