| Differential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31. | |
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MedLine Citation:
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PMID: 7643615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A basic helix-loop-helix phosphoprotein gene, G0S8, was recently isolated by differential screening of cDNA from human blood mononuclear cells stimulated with a T cell mitogen and cycloheximide. In this study, G0S8 expression was examined in normal and malignant hematopoietic cells by Northern blot analysis and reverse transcription-polymerase chain reaction (RT-PCR). G0S8 expression was observed in most fresh samples of acute myelogenous leukemia (AML) (28/30) and most cases of adult acute lymphoblastic leukemia (ALL) (9/11) regardless of clinical classification. G0S8 mRNA was also detected in all cases tested of chronic myelogenous leukemia (CML) in blast crisis. However, G0S8 expression was not detected in CML patients in chronic phase, nor in normal bone marrow or other hematopoietic cells. G0S8 has been mapped using fluorescence in situ hybridization (FISH) to human chromosome 1q31, the same site reported for the B cell homolog BL34/1R20 and within a region implicated in the development of hematological malignancies. The consistent observation of G0S8 mRNA in patient samples of acute leukemia suggests that G0S8 expression may either play a role in leukemogenesis or represent a common consequence of dysregulated growth. |
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Authors:
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H K Wu; H H Heng; X M Shi; D R Forsdyke; L C Tsui; T W Mak; M D Minden; D P Siderovski |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Leukemia Volume: 9 ISSN: 0887-6924 ISO Abbreviation: Leukemia Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1995-09-20 Completed Date: 1995-09-20 Revised Date: 2013-03-04 |
Medline Journal Info:
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Nlm Unique ID: 8704895 Medline TA: Leukemia Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1291-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Toronto, ON, Canada. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/L13391; L13463; L24395; M18105; S59049; X73427; Z32679 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Base Sequence Cell Cycle Chromosomes, Human, Pair 1 DNA Primers / chemistry DNA-Binding Proteins / genetics* Gene Expression Regulation, Neoplastic Helix-Loop-Helix Motifs Humans In Situ Hybridization, Fluorescence Molecular Sequence Data Phosphoproteins / genetics* RGS Proteins* RNA, Messenger / genetics RNA, Neoplasm / genetics Sequence Alignment Sequence Homology, Amino Acid Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/DNA-Binding Proteins; 0/Phosphoproteins; 0/RGS Proteins; 0/RGS2 protein, human; 0/RNA, Messenger; 0/RNA, Neoplasm |
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