| Differential expression of antimicrobial peptides in active and latent tuberculosis and its relationship with diabetes mellitus. | |
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MedLine Citation:
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PMID: 21539878 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Tuberculosis (TB) is one of the most important infectious diseases, causing 1.8 million deaths annually worldwide. This problem has increased because of the association with human immmunodeficiency virus and diabetes mellitus type 2, mainly in developing countries. In the past few years it has been highlighted the significance of antimicrobial peptides in the immunopathogenesis of TB ex vivo and in experimental models studies. In this study we analyzed the expression of CAMP, DEFA1, DEFB4, and DEFB103A in patients with latent TB and progressive TB with and without comorbidity with diabetes mellitus type 2. Antimicrobial peptide gene expression increased during progressive TB, which could be used as a biomarker for reactivation. By contrast, patients with diabetes mellitus type 2 have lower antimicrobial peptides gene expression, suggesting that the lack of its proper production in these patients contribute to enhance the risk for TB reactivation. |
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Authors:
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Irma Gonzalez-Curiel; Julio Castañeda-Delgado; Nallely Lopez-Lopez; Zaida Araujo; Rogelio Hernandez-Pando; Benjamin Gandara-Jasso; Noe Macias-Segura; Antonio Enciso-Moreno; Bruno Rivas-Santiago |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-15 |
Journal Detail:
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Title: Human immunology Volume: - ISSN: 1879-1166 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-5-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8010936 Medline TA: Hum Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Unidad de Investigación Médica, Zacatecas, Instituto Mexicano del Seguro Social, Mexico. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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