| Differential expression of amiloride-sensitive Na+ channel subunits messenger RNA in the rat uterus. | |
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MedLine Citation:
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PMID: 10834307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The expression of the amiloride-sensitive Na+ channel was investigated by reverse transcription-polymerase chain reaction (RT-PCR) in uteri from pregnant and non-pregnant rats. Three subunits (alpha,beta,gamma) of this epithelial Na+ channel have been characterized in the rat. All three subunit mRNAs were present in day 16 pregnant uteri while only alpha and beta subunit mRNAs were detected in uteri from non-pregnant or day 1 postpartum rats. The level of expression of the alpha subunit was similar in day 16 pregnant and non-pregnant animals while the level of expression of the beta subunit was higher in pregnant than in non-pregnant rats. These findings show that amiloride-sensitive Na+ channels are expressed in the rat uterus and that mRNA expression levels of the alpha, beta and gamma subunits are selectively and differentially regulated during pregnancy in the rat. |
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Authors:
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F M Pinto; C G Cintado; A Mérida; A Hidalgo; M L Candenas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Life sciences Volume: 66 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-06-15 Completed Date: 2000-06-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: PL313-7 Citation Subset: IM |
Affiliation:
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Centro de Investigaciones Científicas Isla de La Cartuja, Instituto de Investigaciones Químicas, Sevilla, Spain. mluz@cica.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amiloride
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pharmacology Animals Diuretics / pharmacology Epithelial Sodium Channel Female Gene Expression Regulation Pregnancy RNA, Messenger / metabolism Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction Sodium Channels / genetics*, metabolism Uterus / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Diuretics; 0/Epithelial Sodium Channel; 0/RNA, Messenger; 0/Sodium Channels; 2609-46-3/Amiloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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