Document Detail

Differential expression of activator protein-1 proteins in the pineal gland of Syrian hamster and rat may explain species diversity in arylalkylamine N-acetyltransferase gene expression.
MedLine Citation:
PMID:  16887909     Owner:  NLM     Status:  MEDLINE    
Species differences have been reported for the nighttime regulation of arylalkylamine N-acetyltransferase (AA-NAT), the melatonin rhythm-generating enzyme. In particular, de novo synthesis of stimulatory transcription factors is required for Aa-nat transcription in the Syrian hamster but not in the rat pineal gland. The present work investigated the contribution of phosphorylated cAMP-responsive element-binding protein, c-FOS, c-JUN, and JUN-B in the regulation of Aa-nat transcription in Syrian hamsters compared with rats. The nighttime pattern of cAMP-responsive element-binding protein phosphorylation and regulation by norepinephrine observed in the Syrian hamster was similar to those reported in the rat. On the contrary, strong divergences in c-FOS, c-JUN, and JUN-B expression were observed between both species. In Syrian hamster, predominant expression of c-FOS and c-JUN was observed at the beginning of night, whereas a predominant expression of c-JUN and JUN-B was observed in the late night in rat. The early peak of c-FOS and c-JUN, known to form a stimulatory transcription dimer, suggests that they are involved in the nighttime stimulation of Aa-nat transcription. Indeed, early-night administration of a protein synthesis inhibitor (cycloheximide) markedly decreased AA-NAT mRNA levels in Syrian hamster. In the rat, high levels of JUN-B and c-JUN, constituting an inhibitory transcription dimer, are probably involved in the late-night inhibition of Aa-nat transcription. Early-night administration of cycloheximide actually increased AA-NAT mRNA levels toward the late night. Therefore, composition and timing of the pineal activator protein-1 complexes differ between rat and Syrian hamster and may be an activator (Syrian hamster) or an inhibitor (rat) of Aa-nat transcription.
Natalia Sinitskaya; Anthony Salingre; Paul Klosen; Florent G Revel; Paul Pévet; Valérie Simonneaux
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-08-03
Journal Detail:
Title:  Endocrinology     Volume:  147     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-17     Completed Date:  2006-11-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5052-60     Citation Subset:  AIM; IM    
Institut des Neurosciences Cellulaires et Intégratives, Département de Neurobiologie des Rythmes, UMR-7168/LC2 CNRS-Université Louis Pasteur, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France.
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MeSH Terms
Arylamine N-Acetyltransferase / genetics*
Cyclic AMP Response Element-Binding Protein / analysis*
Cycloheximide / pharmacology
Pineal Gland / chemistry*
Proto-Oncogene Proteins c-fos / analysis*
Proto-Oncogene Proteins c-jun / analysis*
RNA, Messenger / analysis
Rats, Wistar
Receptors, Adrenergic / physiology
Species Specificity
Reg. No./Substance:
0/Cyclic AMP Response Element-Binding Protein; 0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/RNA, Messenger; 0/Receptors, Adrenergic; 66-81-9/Cycloheximide; EC N-Acetyltransferase

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