Document Detail


Differential expression of Toll-like receptor mRNA in White Leghorn and indigenous chicken of India.
MedLine Citation:
PMID:  20668934     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present experiment, the expression profile of Toll-like receptor mRNA in indigenous and pure line chickens was studied. The expression of TLR3, TLR4, TLR5 and TLR7 were quantified in heterophils of Aseel, Kadaknath, Naked neck, Dwarf and White Leghorn lines by Quantitative Real-time PCR. White Leghorns expressed significantly (P < 0.01) higher levels of TLR3 mRNA compared to other lines. TLR4 and TLR5 mRNA were significantly highly expressed in Kadaknath line. Among the TLRs investigated TLR5 was more expressed in all lines studied. TLR7 was highly expressed in indigenous chicken Aseel and Kadaknath than other lines. Dwarf chicken expressed significantly (P < 0.01) lower levels of all TLRs investigated. On the basis of the present study we conclude that the differential expression of TLR mRNA in the heterophils of indigenous and other chicken breeds might contribute to their variable disease resistance/susceptibility.
Authors:
Kannaki T Ramasamy; Maddula R Reddy; Dhanutha N Raveendranathan; Shanmugam Murugesan; Rudra N Chatterjee; Rajkumar Ullengala; Santosh Haunshi
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Publication Detail:
Type:  Journal Article     Date:  2010-07-29
Journal Detail:
Title:  Veterinary research communications     Volume:  34     ISSN:  1573-7446     ISO Abbreviation:  Vet. Res. Commun.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-02     Completed Date:  2011-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100520     Medline TA:  Vet Res Commun     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  633-9     Citation Subset:  IM    
Affiliation:
Project Directorate on Poultry, Hyderabad, 500030,, Andhra Pradesh, India. trkannaki@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Chickens / genetics*
Gene Expression Regulation / physiology*
India
Polymerase Chain Reaction / veterinary*
RNA, Messenger / genetics,  metabolism*
Toll-Like Receptors / genetics*,  metabolism*
Chemical
Reg. No./Substance:
0/RNA, Messenger; 0/Toll-Like Receptors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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