Document Detail

Differential expression of F-actin in in utero fetal wounds.
MedLine Citation:
PMID:  15908293     Owner:  NLM     Status:  MEDLINE    
Fetal skin possesses the capacity to heal a wound by a process of regeneration rather than repair, resulting in the absence of scar formation. The actin cytoskeleton may be involved in this process of scar-free wound healing. The effect of wounding on the expression of contractile filamentous actin (F-actin) was investigated in utero in mice between embryonic day 16 (E16) and embryonic day 18 (E18). Increased F-actin staining in the epidermis of the E16 fetal wounds was observed as early as 3 hours post-wounding, peaking in intensity after 24 hours. By 48 hours the intensity of staining had returned to background levels. In marked contrast, E18 fetal wounds did not show increased epidermal F-actin fluorescence, instead increased staining was observed in cells lying perpendicular to the wound margin within the dermis. This developmental switch from epidermal actin expression in "scar-free" fetal wounds to dermal actin expression in late "scar-forming" gestation wounds may be important in fetal wound contraction and scar-free wound repair.
Allison J Cowin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of dermatology : EJD     Volume:  15     ISSN:  1167-1122     ISO Abbreviation:  Eur J Dermatol     Publication Date:    2005 May-Jun
Date Detail:
Created Date:  2005-05-23     Completed Date:  2005-08-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9206420     Medline TA:  Eur J Dermatol     Country:  France    
Other Details:
Languages:  eng     Pagination:  133-9     Citation Subset:  IM    
Child Health Research Institute, Women's and Children's Hospital, 72 King William Road, North Adelaide, SA, 5006, Australia.
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MeSH Terms
Actins / metabolism*
Disease Models, Animal
Microfilaments / ultrastructure*
Microscopy, Confocal
Pregnancy, Animal*
Prenatal Injuries
Sensitivity and Specificity
Skin / injuries*,  ultrastructure
Skin Physiological Phenomena
Tissue and Organ Harvesting
Wound Healing / physiology*
Reg. No./Substance:

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