Document Detail


Differential expression of the AP-1 transcription factor family members in human colorectal epithelial and neuroendocrine neoplasms.
MedLine Citation:
PMID:  15923159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We immunohistochemically examined 75 human colorectal neoplasms (adenoma, 27; adenocarcinoma, 24; neuroendocrine carcinoma, 24) for the expression of activator protein (AP)-1 family proteins. Nuclear and cytoplasmic expression levels of c-Jun and Fra-1 proteins were markedly elevated in adenomas, adenocarcinomas and neuroendocrine carcinomas compared with nonneoplastic colorectal epithelial cells. JunB also was overexpressed in these tumors but with a predominantly cytoplasmic staining pattern. Overexpression of Fra-2 was evident in carcinomas but less frequent in adenomas. Expression levels of JunD and c-Fos were high in nonneoplastic colorectal epithelial cells and remained so in neoplasms. FosB was undetectable in nonneoplastic and neoplastic colorectal tissues. Neuroendocrine carcinomas exhibited an AP-1 expression profile similar to adenocarcinomas except for infrequent overexpression of c-Jun in poorly differentiated variants. Hierarchical clustering separated the majority of malignant from benign tumors based on AP-1 expression patterns. AP-1 transcription factor family members are expressed differentially in nonneoplastic and neoplastic colorectal tissues. Up-regulation of c-Jun and Fra-1 is an early event in human colorectal tumorigenesis. Overexpression of Fra-2 may participate in tumor progression.
Authors:
Wanghai Zhang; John Hart; Howard L McLeod; Hanlin L Wang
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  124     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-05-30     Completed Date:  2005-08-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  11-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110-1093, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / metabolism,  pathology
Adenoma / metabolism,  pathology
Aged
Aged, 80 and over
Carcinoma, Neuroendocrine / metabolism*,  pathology
Cluster Analysis
Colorectal Neoplasms / metabolism*,  pathology
Epithelial Cells / metabolism*,  pathology
Female
Humans
Immunohistochemistry
Intestinal Mucosa / metabolism
Male
Middle Aged
Prognosis
Proto-Oncogene Proteins c-fos / biosynthesis
Proto-Oncogene Proteins c-jun / biosynthesis
Transcription Factor AP-1 / biosynthesis*
Tumor Markers, Biological / analysis*
Grant Support
ID/Acronym/Agency:
GM63340/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/Transcription Factor AP-1; 0/Tumor Markers, Biological; 0/fos-related antigen 1

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