Document Detail

Differential elastin and tenascin immunolabeling in the uterosacral ligaments in postmenopausal women with and without pelvic organ prolapse.
MedLine Citation:
PMID:  18155129     Owner:  NLM     Status:  MEDLINE    
Connective tissue, consisting mainly of collagen and structural glycoproteins, is an important part of the supportive structures of the genitourinary region. Relatively few data have been published with respect to the role of elastin and glycoproteins in pelvic organ prolapse (POP). Connective tissue of the uterosacral ligament in postmenopausal women with and without genital prolapse was compared. Fifty-nine consecutive women referred for hysterectomy were included in the study. The patients had POP or benign gynecological disease (e.g. myoma of the uterus). Tissue samples from the uterosacral ligament were investigated for localization and distribution of tenascin and elastin using immunofluorescence microscopy. Tissue samples of women with prolapse showed a significantly (p<0.001) weaker immunofluorescent labeling of tenascin compared to samples taken from women without prolapse. Tenascin was detectable in tissues of all women with POP, whereas its immunolabeling was decreased in the uterosacral ligament in women without POP. Intact elastin fibers were observed in tissues of all women without POP, whereas elastin was undetectable or sometimes fragmented in the uterosacral ligament in women with POP. Greater amounts of tenascin and lesser amounts of elastin were therefore found in patients with POP. These results suggest that an altered turnover of connective tissue in the uterosacral ligament might be responsible for the presence of pelvic floor relaxation in postmenopausal women. These data indicate a complex architecture of the extracellular matrix in the uterosacral ligaments, with marked differences in tenascin and elastin expression between postmenopausal women with or without POP.
Christian Goepel
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Publication Detail:
Type:  Journal Article     Date:  2007-12-21
Journal Detail:
Title:  Acta histochemica     Volume:  110     ISSN:  0065-1281     ISO Abbreviation:  Acta Histochem.     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-29     Completed Date:  2008-08-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370320     Medline TA:  Acta Histochem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  204-9     Citation Subset:  IM    
Department of Gynecology, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Strabe 40, D-O6097 Halle (Saale), Germany.
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MeSH Terms
Aged, 80 and over
Collagen / analysis
Connective Tissue / metabolism,  pathology
Elastin / analysis*
Glycoproteins / analysis
Ligaments / chemistry*
Microscopy, Fluorescence
Middle Aged
Myoma / metabolism,  pathology
Pelvic Floor / pathology
Sacrum / pathology
Tenascin / analysis*
Uterine Prolapse / metabolism*,  pathology
Uterus / pathology
Reg. No./Substance:
0/Glycoproteins; 0/Tenascin; 9007-34-5/Collagen; 9007-58-3/Elastin

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