| Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice. | |
| | |
MedLine Citation:
|
PMID: 16716524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Huntington's disease is a fatal neurodegenerative disorder caused by a mutation of the huntingtin gene and involves progressive motor abnormalities (including chorea), cognitive deficits (dementia) as well as psychiatric symptoms. We have previously demonstrated that environmental enrichment slows the onset and progression of Huntington's disease in transgenic mice. Here, we investigated the effects of enhanced physical exercise on disease progression and brain-derived neurotrophic factor expression. Standard-housed Huntington's disease mice developed phenotypic rear-paw clasping by 16 weeks of age, displayed abnormal rearing behavior, deficits in motor co-ordination and of spatial working memory. Huntington's disease mice with access to running wheels exhibited delayed onset of rear-paw clasping, normalized levels of rearing behavior and amelioration of the cognitive deficits. However, in contrast to our previous environmental enrichment studies, there was no rescue of motor coordination deficits in wheel-running Huntington's disease mice. An abnormal accumulation of brain-derived neurotrophic factor protein in the frontal cortex of Huntington's disease mice was unaffected by running. Striatal and hippocampal brain-derived neurotrophic factor protein levels were unchanged. Brain-derived neurotrophic factor mRNA levels were reduced in the anterior cortex, striatum and hippocampus of Huntington's disease mice, and only striatal deficits were ameliorated by running. Overall, we show that voluntary physical exercise delays the onset of Huntington's disease and the decline in cognitive ability. In addition, our results reveal that some aspects of hippocampal dependent memory are not entirely reliant on sustained hippocampal brain-derived neurotrophic factor expression. |
| | |
Authors:
|
T Y C Pang; N C Stam; J Nithianantharajah; M L Howard; A J Hannan |
Related Documents
:
|
20813214 - Proteasome and oxidative phoshorylation changes may explain why aging is a risk factor ... 3285724 - Mitochondrial abnormalities in choroid plexus of leigh disease. 21347014 - Disease propagation analysis and mitigation strategies for effective mass dispensing. 11479594 - A novel pantothenate kinase gene (pank2) is defective in hallervorden-spatz syndrome. 17105434 - Molecular and biochemical features in alzheimer's disease. 23517644 - Inhalation delivery of protein therapeutics. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-05-22 |
Journal Detail:
|
Title: Neuroscience Volume: 141 ISSN: 0306-4522 ISO Abbreviation: Neuroscience Publication Date: 2006 Aug |
Date Detail:
|
Created Date: 2006-07-24 Completed Date: 2006-10-04 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States |
Other Details:
|
Languages: eng Pagination: 569-84 Citation Subset: IM |
Affiliation:
|
Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia. t.pang@hfi.unimelb.edu.au |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Analysis of Variance Animals Behavior, Animal Brain-Derived Neurotrophic Factor / deficiency*, genetics Corpus Striatum / metabolism Disease Models, Animal Exploratory Behavior / physiology Frontal Lobe / metabolism Gene Expression Regulation / genetics Huntington Disease / genetics, metabolism*, physiopathology, rehabilitation* Male Maze Learning / physiology Mice Mice, Transgenic Nerve Tissue Proteins / genetics Nuclear Proteins / genetics Physical Conditioning, Animal / methods* Psychomotor Performance / physiology RNA, Messenger / metabolism Reaction Time / genetics Reverse Transcriptase Polymerase Chain Reaction / methods Running / physiology Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Brain-Derived Neurotrophic Factor; 0/Huntington protein, mouse; 0/Nerve Tissue Proteins; 0/Nuclear Proteins; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Habenula lesions alter synaptic plasticity within the fimbria-accumbens pathway in the rat.
Next Document: Sensitivity of rat temporalis muscle afferent fibers to peripheral N-methyl-D-aspartate receptor act...