Document Detail


Differential effects of upper gastrointestinal fill on milk ingestion and nipple attachment in the suckling rat.
MedLine Citation:
PMID:  7201938     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Milk intake and nipple attachment behaviors were studied in the natural suckling situation after gastrointestinal preloading. Rat pups, deprived of their dam for 9 hr at 1, 10, or 20 days of age, were preloaded by gavage with volumes ranging from 2 to 16% of their body weight and returned to suckle. Preloads of artificial bitch's milk decreased the intake of mother's milk in a volume-related manner at all ages. At 1 and 10 days 4% preloads decreased milk intake without affecting attachment behaviors; larger preloads of 8 and 16% decreased intake and reduced the incidence of attachment. At 20 days of age small and large preloads decreased both incidence of attachment and milk intake. Preloads up to 8% of body weight had no effect on latency to attach at any age. Complete subdiaphragmatic bilateral vagotomy increased milk intake of 7-9 day-old pups fed automatically through an anterior mouth cannula in a nonsuckling situation. Vagotomy combined with spinal cordotomy (T2-T3) resulted in a synergistic hyperphagia and massive distension of the upper GI tract. The results indicate that suckling rats can control their intake of mother's milk while remaining attached to a nipple as early as 1 day of age. The suppression of ingestion in response to GI filling appears to be mediated by visceral afferent activity. Conversely, attachment behaviors are less affected by GI fill. This suggests that ingestive behaviors and attachment behaviors have different controls during the 1st 10 days of postnatal development.
Authors:
D N Lorenz; S B Ellis; A N Epstein
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental psychobiology     Volume:  15     ISSN:  0012-1630     ISO Abbreviation:  Dev Psychobiol     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-10-21     Completed Date:  1982-10-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  309-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Behavior, Animal / physiology
Body Weight
Colostrum / physiology
Digestive System / innervation*
Food, Formulated
Humans
Hyperphagia / etiology
Milk
Nipples
Rats
Rats, Inbred Strains
Reaction Time
Sodium Chloride / pharmacology
Sucking Behavior / drug effects,  physiology*
Vagotomy
Grant Support
ID/Acronym/Agency:
03469//PHS HHS; 15092//PHS HHS
Chemical
Reg. No./Substance:
7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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