Document Detail

Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain-derived neurotrophic factor and synaptotagmin I.
MedLine Citation:
PMID:  19451201     Owner:  NLM     Status:  MEDLINE    
Chronic exercise has been reported to improve cognitive function. However, whether and how different types of exercise affect various learning and memory tasks remain uncertain. To address this issue, male BALB/c mice were trained for 4 weeks under two different exercise protocols: moderate treadmill running or voluntary wheel running. After exercise training, their spatial memory and aversive memory were evaluated by a Morris water maze and by one-trial passive avoidance (PA), respectively. Levels of neural plasticity-related proteins, i.e. brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB) and synaptotagmin I (Syt I), in hippocampus and amygdala were determined by ELISA or immunoblotting. Finally, the functional roles of these proteins in the basolateral amygdala were verified by locally blocking them with K252a (a TrkB kinase inhibitor), or lentivirus expressing Syt I shRNA. We found that (1) although both moderate treadmill running and wheel running improved the Morris water maze performance, only the former improved PA performance; (2) likewise, both exercise protocols upregulated the BDNF-TrkB pathway and Syt I in the hippocampus, whereas only treadmill exercise upregulated their expression levels in the amygdala; (3) local injection of K252a abolished the treadmill exercise-facilitated PA performance and upregulation of amygdalar TrkB and Syt I; and (4) local administration of Syt I shRNA abolished the treadmill exercise-facilitated PA performance and upregulation of amygdalar Syt I. Therefore, our results support the notion that different forms of exercise induce neuroplasticity changes in different brain regions, and thus exert diverse effects on various forms of learning and memory.
Yu-Fan Liu; Hsiun-ing Chen; Chao-Liang Wu; Yu-Min Kuo; Lung Yu; A-Min Huang; Fong-Sen Wu; Jih-Ing Chuang; Chauying J Jen
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-18
Journal Detail:
Title:  The Journal of physiology     Volume:  587     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-01     Completed Date:  2009-10-09     Revised Date:  2010-09-27    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  3221-31     Citation Subset:  IM    
Institute of Basic Medical Sciences, Department of Physiology, National Cheng Kung University, Tainan, Taiwan
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MeSH Terms
Amygdala / physiology
Avoidance Learning / drug effects,  physiology
Base Sequence
Brain-Derived Neurotrophic Factor / physiology*
Carbazoles / pharmacology
Corticosterone / blood
Hippocampus / physiology
Indole Alkaloids / pharmacology
Learning / drug effects,  physiology*
Maze Learning / drug effects,  physiology
Memory / drug effects,  physiology*
Mice, Inbred BALB C
Motor Activity / physiology*
Muscle, Skeletal / physiology
Neuronal Plasticity / physiology
RNA, Small Interfering / genetics
Receptor, trkB / antagonists & inhibitors,  physiology
Running / physiology
Synaptotagmin I / antagonists & inhibitors,  genetics,  physiology*
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 0/Carbazoles; 0/Indole Alkaloids; 0/RNA, Small Interfering; 0/Synaptotagmin I; 50-22-6/Corticosterone; 97161-97-2/K 252; EC, trkB

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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