Document Detail

Differential effects of sodium butyrate and hyperosmolality on the modulation of alkaline phosphatases of LoVo cells.
MedLine Citation:
PMID:  2328777     Owner:  NLM     Status:  MEDLINE    
LoVo cells produce term-placental and intestinal alkaline phosphatases. Hyperosmolality and sodium butyrate increase the levels of both, but the effect of sodium butyrate is more pronounced on the intestinal enzyme. When applied together, induction of term-placental alkaline phosphatase is additive and that of the intestinal enzyme is synergistic. Induction by either stimulus or by their mixture is independent of cell density. However, whereas the effect of hyperosmolality is readily reversible, induction by sodium butyrate is not. No synergistic increase in intestinal alkaline phosphatase activity occurs when cells are sequentially treated with hyperosmolality and sodium butyrate or vice versa. This indicates that only when applied concurrently does one inducer amplify the effect of the other. Since the normal colonic mucosa produces intestinal alkaline phosphatase, its predominant induction by sodium butyrate in LoVo cells may reflect a more differentiated state.
F Herz; M Halwer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental cell research     Volume:  188     ISSN:  0014-4827     ISO Abbreviation:  Exp. Cell Res.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-05-25     Completed Date:  1990-05-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0373226     Medline TA:  Exp Cell Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  50-4     Citation Subset:  IM    
Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467-2401.
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MeSH Terms
Alkaline Phosphatase / metabolism*
Butyrates / pharmacology*
Butyric Acid
Butyric Acids / pharmacology*
Carcinoma / enzymology,  pathology*
Colonic Neoplasms / enzymology,  pathology*
Osmolar Concentration
Tumor Cells, Cultured / drug effects,  enzymology,  pathology
Reg. No./Substance:
0/Butyrates; 0/Butyric Acids; 107-92-6/Butyric Acid; EC Phosphatase

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