Document Detail


Differential effects of simple vs. complex carbohydrates on VLDL secretion rates and HDL metabolism in the guinea pig.
MedLine Citation:
PMID:  7742353     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Guinea pigs were fed isocaloric diets containing 52% (w/w) carbohydrate, either sucrose or starch, to investigate effects of simple vs. complex carbohydrates on plasma VLDL and HDL metabolism. Plasma cholesterol concentrations were not different between dietary groups while plasma triacylglycerol (TAG) and VLDL cholesterol levels were significantly increased in animals fed the sucrose diet (P < 0.05). Hepatic VLDL TAG secretion rates measured following intravenous injection of Triton WR-1339 were not affected by carbohydrate type whereas the rate of apo B secretion was 1.9-fold higher in sucrose fed animals (P < 0.02). Nascent VLDL from the sucrose group contained less TAG per apo B suggesting that the higher plasma TAG in animals fed simple carbohydrates results from increased secretion of VLDL particles with lower TAG content. Sucrose fed animals exhibited higher concentrations of hepatic free cholesterol (P < 0.01) while hepatic TAG levels and acyl CoA:cholesterol acyltransferase (ACAT) activity were not different between groups. Plasma HDL cholesterol concentrations and composition, and plasma lecithin cholesterol acyltransferase (LCAT) activity were not affected by diet yet there was a positive correlation between HDL cholesteryl ester content and LCAT activities (r = 0.70, P < 0.05). Hepatic membranes from the sucrose group had a higher hepatic HDL binding protein number (Bmax) with no changes in the dissociation constant (Kd). These results suggest that at the same carbohydrate energy intake, simple sugars induce modest changes in HDL metabolism while VLDL metabolism is affected at multiple sites, as indicated by the higher concentrations of hepatic cholesterol, dissociation in the synthesis rates of VLDL components, and compositional changes in nascent and mature VLDL.
Authors:
M L Fernandez; G Abdel-Fattah; D J McNamara
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1256     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-06-12     Completed Date:  1995-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  31-8     Citation Subset:  IM    
Affiliation:
Department of Nutritional Sciences, University of Arizona, Tucson 85721, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cholesterol / blood,  metabolism
Dietary Carbohydrates / administration & dosage,  pharmacology*
Guinea Pigs
Lipoproteins, HDL / blood*
Lipoproteins, VLDL / blood*
Liver / metabolism
Male
Phosphatidylcholine-Sterol O-Acyltransferase / metabolism
Starch / administration & dosage,  pharmacology
Sterol O-Acyltransferase / metabolism
Sucrose / administration & dosage,  pharmacology
Triglycerides / blood,  metabolism
Chemical
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Lipoproteins, HDL; 0/Lipoproteins, VLDL; 0/Triglycerides; 57-50-1/Sucrose; 57-88-5/Cholesterol; 9005-25-8/Starch; EC 2.3.1.26/Sterol O-Acyltransferase; EC 2.3.1.43/Phosphatidylcholine-Sterol O-Acyltransferase

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