Document Detail


Differential effects of reperfusion on incidence of ventricular arrhythmias and recovery of ventricular function at 4 days following coronary occlusion.
MedLine Citation:
PMID:  3577998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the influence of coronary reperfusion on ventricular arrhythmias and ventricular function at 4 days post occlusion, anesthetized dogs randomly received no occlusion (sham), permanent occlusion, or 1-, 2-, 3-, 4-, or 6-hour occlusions of the left anterior descending coronary artery, followed by reperfusion. An ambulatory ECG was recorded between 78 and 96 hours. The total runs of ventricular tachycardia were 1 +/- 0 (sham), 155 +/- 101 (1 hour), 66 +/- 32 (2 hours), 56 +/- 35 (3 hours), 167 +/- 68 (4 hours), 942 +/- 618 (6 hours), and 1422 +/- 486 (permanent occlusion); the runs of ventricular tachycardia were significantly less in the combined 1- to 4-hour groups (93 +/- 24) compared to the 6-hour and permanent occlusion groups (1282 +/- 384; p less than 0.006). Similar results were obtained for the number of hours in which ventricular tachycardia or frequent ventricular premature beats occurred. At 96 hours, improvement in percent systolic wall thickening of the ischemic myocardium assessed by two-dimensional echocardiography was seen in the group reperfused at 1 hour (p less than 0.01). Similar results were obtained for the reduction in degrees of wall circumference showing systolic thinning. In summary, at 4 days post occlusion in a dog model, spontaneous ventricular arrhythmias are reduced by reperfusion within 4 hours, while return of ventricular function is only improved by reperfusion within approximately 1 hour of coronary occlusion.
Authors:
J M Arnold; E M Antman; K Przyklenk; E Braunwald; T Sandor; M T Vivaldi; F J Schoen; R A Kloner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American heart journal     Volume:  113     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-06-02     Completed Date:  1987-06-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1055-65     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arrhythmias, Cardiac / etiology*,  physiopathology
Arterial Occlusive Diseases / physiopathology
Coronary Circulation*
Dogs
Electrocardiography
Female
Heart Ventricles / pathology,  physiopathology
Hemodynamics
Male
Myocardial Infarction / physiopathology*
Necrosis
Perfusion
Random Allocation
Time Factors
Grant Support
ID/Acronym/Agency:
HL-23140/HL/NHLBI NIH HHS; HL-26215/HL/NHLBI NIH HHS; HL-28048/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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