Document Detail

Differential effects of propofol and nitrous oxide on posterior tibial nerve somatosensory cortical evoked potentials during alfentanil anaesthesia.
MedLine Citation:
PMID:  2025476     Owner:  NLM     Status:  MEDLINE    
We have studied differential effects of propofol and nitrous oxide on posterior tibial nerve somatosensory evoked potentials (PTN-SEP) during a continuous infusion of alfentanil. In study 1, 14 patients received initially 66% nitrous oxide in oxygen, which was replaced 90 min after incision by propofol 6 mg kg-1 h-1. This substitution resulted in a significant increase in mean P1N1 amplitude from 1.01 (SD 1.14) microV to 2.61 (2.17) microV (P less than 0.01), while amplitudes of later peaks were unaffected. Latencies of peaks N1, P2 and N2 increased after the substitution. In study 2, 30 patients undergoing spinal surgery received either alfentanil-nitrous oxide anaesthesia (group I, n = 15) or alfentanil-propofol anaesthesia (group II, n = 15). P1N1 amplitude was significantly greater in group II (3.24 (1.08) microV) than in group I (1.64 (0.97) microV) (P less than 0.01). Latencies of peaks P2 and N2 were of significantly greater duration in group II than in group I. Because early cortical PTN-SEP peaks were preserved better during alfentanil-propofol anaesthesia we conclude that this combination may be a suitable alternative to alfentanil-nitrous oxide anaesthesia, when spinal cord function monitoring with PTN-SEP is indicated.
C J Kalkman; H Traast; W W Zuurmond; J G Bovill
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  66     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-06-07     Completed Date:  1991-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  483-9     Citation Subset:  IM    
Department of Anaesthesiology, Academic Medical Centre, Amsterdam, The Netherlands.
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MeSH Terms
Anesthesia, Intravenous*
Evoked Potentials, Somatosensory / drug effects*
Middle Aged
Monitoring, Physiologic / methods
Nitrous Oxide*
Scoliosis / surgery
Spinal Fractures / surgery
Spine / surgery
Tibial Nerve / drug effects*,  physiology
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 2078-54-8/Propofol; 71195-58-9/Alfentanil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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