Document Detail


Differential effects of metal ions on type A and type B monoamine oxidase activities in rat brain and liver mitochondria.
MedLine Citation:
PMID:  1435620     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the hypothesis that neurotoxic metals can exert their toxicity through the direct inhibition of monoamine oxidases (MAOs), the effects of several neurotoxic metal ions on type A (MAO-A) and type B (MAO-B) monoamine oxidase activities in rat forebrain nonsynaptic mitochondria and rat liver mitochondria were studied. At pathophysiological levels (10-100 microM), Cu2+ and Cd2+ are good inhibitors of brain mitochondrial MAO-A and, to a lesser extent, liver mitochondrial MAO-A. The inhibition of MAO-B activities in brain and liver mitochondria by Cu2+ and Cd2+ is only detected at the higher end of the concentration range (i.e., 50-100 microM). At the pathophysiological level of 0.5 mM, Al3+ only inhibits brain mitochondrial MAO-A but at the higher level of 2.5 mM, it inhibits both forms of MAO in brain as well as liver mitochondria. Even at toxic levels (e.g., 5 mM), neither Mn2+ nor Li+ inhibits the activities of MAO-A and MAO-B in brain and liver mitochondria. Our results are consistent with the hypothesis that some neurotoxic metals can exert their toxicity through the direct inhibition of the isoforms of MAO. Our data also suggest that the selective inhibition of brain MAO-A by Cu2+ and Cd2+ may assume pathophysiological importance in the neurotoxicity of copper and cadmium.
Authors:
T K Leung; L Lim; J C Lai
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Metabolic brain disease     Volume:  7     ISSN:  0885-7490     ISO Abbreviation:  Metab Brain Dis     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-12-08     Completed Date:  1992-12-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610370     Medline TA:  Metab Brain Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  139-46     Citation Subset:  IM    
Affiliation:
Department of Neurochemistry, University of London, Queen Square, U.K.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / enzymology*
Ions
Isoenzymes / metabolism*
Male
Metals / pharmacology*
Mitochondria / enzymology*
Mitochondria, Liver / enzymology*
Monoamine Oxidase / metabolism*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Ions; 0/Isoenzymes; 0/Metals; EC 1.4.3.4/Monoamine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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