Document Detail

Differential effects of melanocortin peptides on ingestive behaviour in rats: evidence against the involvement of MC(3) receptor in the regulation of food intake.
MedLine Citation:
PMID:  10729619     Owner:  NLM     Status:  MEDLINE    
The pro-opiomelanocortin-derived peptides decrease food intake possibly via MC4 receptor. In this study we compared the effects of alpha-melanocyte-stimulating hormone (MSH), beta-MSH and gamma(1)-MSH (0.2, 1.0 and 5.0 microg, i.c.v.) on food intake. alpha-MSH and beta-MSH inhibited spontaneous food intake in a dose dependent manner, whereas the gamma(1)-MSH did not. alpha-MSH and beta-MSH but not gamma(1)-MSH (all 5.0 microg, i.c.v.) inhibited fasting-induced food intake about 50%. None of the three peptides inhibited fluid consumption in water-deprived (24 h) rats. It is suggested that MC(3) receptor, activated selectively by gamma(1)-MSH, is not involved in the regulation of food intake.
A Kask; L Rägo; J E Wikberg; H B Schiöth
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  283     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-05-23     Completed Date:  2000-05-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
Department of Pharmacology, Faculty of Medicine, University of Tartu, Ravila 19, 50411, Tartu, Estonia.
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MeSH Terms
Eating / drug effects*,  physiology*
Feeding Behavior / drug effects*,  physiology*
Rats, Wistar
Receptor, Melanocortin, Type 3
Receptors, Corticotropin / drug effects*,  metabolism*
Time Factors
alpha-MSH / metabolism*,  pharmacology*
beta-MSH / metabolism*,  pharmacology*
gamma-MSH / metabolism*,  pharmacology*
Reg. No./Substance:
0/Receptor, Melanocortin, Type 3; 0/Receptors, Corticotropin; 0/beta-MSH; 0/gamma-MSH; 581-05-5/alpha-MSH

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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