| Differential effects of low versus high amounts of weight supported treadmill training in spinal rats. | |
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MedLine Citation:
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PMID: 21476782 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Intensive weight supported treadmill training improves locomotor function following spinal cord injury. Due to a number of factors, undergoing intensive sessions of training may not be feasible. Whether reduced amounts of training are sufficient to enhance spinal plasticity to a level that is necessary for improving function is not known. The focus of the present study was to assess differences in recovery of locomotor function and spinal plasticity as a function of the amount of steps during weight supported treadmill training in a rodent model of spinal cord injury. Rats were spinally transected at 5 days of age. At 28 days of age, a robotic system was used to implement a weight supported treadmill training program of either 100 or 1000 steps/training session daily for 4 weeks. Antibodies for BDNF, TrkB and the presynaptic marker, synaptophysin, were used to examine the expression of these proteins in the ventral horn of the lumbar spinal cord. Rats that received weight supported treadmill training performed better stepping relative to untrained rats, but only the rats that received 1000 steps/training session recovered locomotor function that resembled normal patterns. Only the rats that received 1000 steps/training session recovered normal levels of synaptophysin immunoreactivity around motor neurons. Weight supported treadmill training consisting of either 100 or 1000 steps/training session increased BDNF immunoreactivity in the ventral horn of the lumbar spinal cord. TrkB expression in the ventral horn was not affected by spinal cord transection or weight supported treadmill training. Synaptophysin expression, but not BDNF or TrkB expression was correlated with the recovery of stepping function. These findings suggested that a high amount of weight supported treadmill training was necessary for restoring synaptic connections to motor neurons within the locomotor generating circuitry. Although a high amount of training was best for recovery, low amounts of training were associated with incremental gains in function and increased BDNF levels. |
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Authors:
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Ray de Leon; Pamela Anne See; Cheryl H T Chow |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-8 |
Journal Detail:
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Title: Journal of neurotrauma Volume: - ISSN: 1557-9042 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8811626 Medline TA: J Neurotrauma Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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California State University, Los Angeles, Kinesiology, Los Angeles, United States; rdeleon@calstatela.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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