Document Detail

Differential effects of ketamine and midazolam on heart rate variability.
MedLine Citation:
PMID:  8590488     Owner:  NLM     Status:  MEDLINE    
Alterations in autonomic activity caused by anaesthesia can be assessed by spectral analysis of heart rate variability (HRV). This study examined the effects of ketamine and midazolam on HRV. Thirty patients of ASA PS 1 were studied. Fifteen were given ketamine (2 and 15 received midazolam (0.3, iv. The RR intervals of ECG were measured before and after induction of anaesthesia for ten minutes during spontaneous respiration. Power spectral density of the data was computed using fast Fourier transform. The spectral peaks within each measurement were calculated: low frequency area (LF, 0.04-0.15 Hz), high frequency area (HF, 0.15-0.5 Hz), and total power (TP, 0.04-0.5 Hz). Normalized unit power was derived as follows: low frequency area (nuLF): LF/TP x 100%, high frequency area (nuHF): HF/TP x 100%. Both ketamine and midazolam caused reductions in all measurements of HRV power (P < 0.05). However, ketamine increased nuLF from 64 +/- 14% to 75 +/- 13% (P < 0.05) and decreased nuHF from 36 +/- 14% to 25 +/- 13% (P < 0.05), while midazolam decreased nuLF from 66 +/- 15% to 54 +/- 14% (P < 0.05) and increased nuHF from 34 +/- 15% to 46 +/- 14% (P < 0.05). These results documented that both ketamine and midazolam reduced the total power and all frequency components of power in spite of their opposing effects on autonomic nervous activity. However, normalized unit power showed the expected sympathetic activation with ketamine and sympathetic depression with midazolam since ketamine increased nuLF and midazolam decreased nuLF.
T Komatsu; P K Singh; T Kimura; K Nishiwaki; K Bando; Y Shimada
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  42     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-03-25     Completed Date:  1996-03-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1003-9     Citation Subset:  IM    
Department of Anesthesiology, Nagoya University School of Medicine, Japan.
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MeSH Terms
Anesthesia, Intravenous
Anesthetics, Dissociative / administration & dosage,  pharmacology*
Anesthetics, Intravenous / administration & dosage,  pharmacology*
Autonomic Nervous System / drug effects
Electrocardiography / drug effects
Fourier Analysis
Heart Conduction System / drug effects
Heart Rate / drug effects*
Ketamine / administration & dosage,  pharmacology*
Midazolam / administration & dosage,  pharmacology*
Respiration / drug effects
Signal Processing, Computer-Assisted
Reg. No./Substance:
0/Anesthetics, Dissociative; 0/Anesthetics, Intravenous; 59467-70-8/Midazolam; 6740-88-1/Ketamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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