| Differential effects of ketamine and midazolam on heart rate variability. | |
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MedLine Citation:
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PMID: 8590488 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alterations in autonomic activity caused by anaesthesia can be assessed by spectral analysis of heart rate variability (HRV). This study examined the effects of ketamine and midazolam on HRV. Thirty patients of ASA PS 1 were studied. Fifteen were given ketamine (2 mg.kg-1) and 15 received midazolam (0.3 mg.kg-1), iv. The RR intervals of ECG were measured before and after induction of anaesthesia for ten minutes during spontaneous respiration. Power spectral density of the data was computed using fast Fourier transform. The spectral peaks within each measurement were calculated: low frequency area (LF, 0.04-0.15 Hz), high frequency area (HF, 0.15-0.5 Hz), and total power (TP, 0.04-0.5 Hz). Normalized unit power was derived as follows: low frequency area (nuLF): LF/TP x 100%, high frequency area (nuHF): HF/TP x 100%. Both ketamine and midazolam caused reductions in all measurements of HRV power (P < 0.05). However, ketamine increased nuLF from 64 +/- 14% to 75 +/- 13% (P < 0.05) and decreased nuHF from 36 +/- 14% to 25 +/- 13% (P < 0.05), while midazolam decreased nuLF from 66 +/- 15% to 54 +/- 14% (P < 0.05) and increased nuHF from 34 +/- 15% to 46 +/- 14% (P < 0.05). These results documented that both ketamine and midazolam reduced the total power and all frequency components of power in spite of their opposing effects on autonomic nervous activity. However, normalized unit power showed the expected sympathetic activation with ketamine and sympathetic depression with midazolam since ketamine increased nuLF and midazolam decreased nuLF. |
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Authors:
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T Komatsu; P K Singh; T Kimura; K Nishiwaki; K Bando; Y Shimada |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Canadian journal of anaesthesia = Journal canadien d'anesthésie Volume: 42 ISSN: 0832-610X ISO Abbreviation: Can J Anaesth Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1996-03-25 Completed Date: 1996-03-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701709 Medline TA: Can J Anaesth Country: CANADA |
Other Details:
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Languages: eng Pagination: 1003-9 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Nagoya University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthesia, Intravenous Anesthetics, Dissociative / administration & dosage, pharmacology* Anesthetics, Intravenous / administration & dosage, pharmacology* Autonomic Nervous System / drug effects Electrocardiography / drug effects Female Fourier Analysis Heart Conduction System / drug effects Heart Rate / drug effects* Humans Ketamine / administration & dosage, pharmacology* Male Midazolam / administration & dosage, pharmacology* Respiration / drug effects Signal Processing, Computer-Assisted |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Dissociative; 0/Anesthetics, Intravenous; 59467-70-8/Midazolam; 6740-88-1/Ketamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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