Document Detail

Differential effects of intravenous anaesthetic agents on the response of rat mesenteric microcirculation in vivo after haemorrhage.
MedLine Citation:
PMID:  11883388     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The differential effects of i.v. anaesthesia on the response of the mesenteric microcirculation after haemorrhage in vivo are previously unexplored. METHODS: Male Wistar rats (n=56) were anaesthetized intravenously either with propofol and fentanyl (propofol/fentanyl), ketamine or thiopental. A tracheostomy and carotid cannulation were performed and the mesentery surgically prepared for observation of the microcirculation using fluorescent in vivo microscopy. Animals were allocated to one of three groups: control, haemorrhage or haemorrhage re-infusion. RESULTS: After haemorrhage, the response of the microcirculation differed during propofol/fentanyl, ketamine and thiopental anaesthesia. During propofol/fentanyl anaesthesia there was constriction of arterioles (-16.7 (3.9)%), venules (-5.9 (1.7)) and capillaries (-16.3 (2.8)) (n=12). During ketamine and thiopental anaesthesia both constriction and dilation was observed. After haemorrhage and re-infusion, macromolecular leak occurred from venules during propofol/fentanyl and thiopental anaesthesia (P<0.05), but not during ketamine anaesthesia. CONCLUSION: In summary, i.v. anaesthetic agents differentially alter the response of the mesenteric microcirculation to haemorrhage.
Z L S Brookes; N J Brown; C S Reilly
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  88     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-03-06     Completed Date:  2002-04-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  255-63     Citation Subset:  IM    
Division of Clinical Sciences, University of Sheffield, Royal Hallamshire Hospital, UK.
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MeSH Terms
Anesthetics, Combined / pharmacology
Anesthetics, Intravenous / pharmacology*
Fentanyl / pharmacology
Hemodynamics / drug effects
Hemorrhage / physiopathology*
Ketamine / pharmacology
Microcirculation / drug effects
Microscopy, Fluorescence
Propofol / pharmacology
Rats, Wistar
Splanchnic Circulation / drug effects*
Thiopental / pharmacology
Vasoconstriction / drug effects
Vasodilation / drug effects
Reg. No./Substance:
0/Anesthetics, Combined; 0/Anesthetics, Intravenous; 2078-54-8/Propofol; 437-38-7/Fentanyl; 6740-88-1/Ketamine; 76-75-5/Thiopental

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