| Differential effects of intrauterine and postnatal brain growth failure in infants of very low birth weight. | |
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MedLine Citation:
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PMID: 2910047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the contribution of brain growth failure to outcome in infants of very low birth weight (VLBW; less than 1.5 kg) who were appropriate for gestational age (AGA; n = 379) or small for gestational age (SGA; n = 102). Growth was assessed at birth, term, and 8 and 20 months' corrected age and results of a Bayley Mental Developmental Index (MDI) and neurologic examination were evaluated at 20 months of age. Both groups had similar 20-month MDI scores (93 vs 90) and similar rates of neurologic impairment (14% vs 10%). More SGA infants (25%) than AGA infants (14%) had a subnormal head circumference at 8 months' corrected age, indicating failure to catch up in head growth. Subnormal head size at 8 months predicted the 20-month MDI score for both groups. However, multivariate analysis indicated that, whereas subnormal 8-month head size was directly associated with the MDI score in AGA children, in SGA children 8-month head size was not significantly related to the MDI score when neonatal illness, neurologic impairment, socioeconomic status, and race were controlled for. We conclude that in AGA VLBW infants, subnormal head size at 8 months results from major neonatal illness and has adverse later effects. In SGA infants, subnormal head size at 8 months has many causes, including growth retardation in utero, which may not have an adverse effect on outcome; if subnormal head size is superimposed with neonatal illness, a poorer outcome is likely. |
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Authors:
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M Hack; N Breslau; A A Fanaroff |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of diseases of children (1960) Volume: 143 ISSN: 0002-922X ISO Abbreviation: Am. J. Dis. Child. Publication Date: 1989 Jan |
Date Detail:
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Created Date: 1989-02-03 Completed Date: 1989-02-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370471 Medline TA: Am J Dis Child Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 63-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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pathology* Female Fetal Growth Retardation / pathology, psychology* Follow-Up Studies Humans Infant Infant, Low Birth Weight / growth & development, psychology* Infant, Newborn Infant, Newborn, Diseases / complications Infant, Small for Gestational Age / growth & development, psychology* Intelligence* Pregnancy Pregnancy Complications Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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