Document Detail

Differential effects of hypothermia on early and late epileptiform events after severe hypoxia in preterm fetal sheep.
MedLine Citation:
PMID:  17093117     Owner:  NLM     Status:  MEDLINE    
Moderate cerebral hypothermia is consistently neuroprotective after experimental hypoxia-ischemia; however, its mechanisms remain poorly defined. Using a model of complete umbilical cord occlusion for 25 min in 0.7 gestation fetal sheep, we examined the effects of cerebral hypothermia (fetal extradural temperature reduced from 39.5 +/- 0.2 degrees C to <34 degrees C; mean +/- SD), from 90 min to 70 h after the end of the insult, on postocclusion epileptiform activity. In the first 6 h after the end of occlusion, fetal electroencephalographic (EEG) activity was abnormal with a mixture of fast and slow epileptiform transients superimposed on a suppressed background; seizures started a mean of 8 h after occlusion. There was a close correlation between numbers of these EEG transients and subsequent neuronal loss in the striatum after 3 days recovery (r(2) = 0.65, P = 0.008). Hypothermia was associated with a marked reduction in numbers of epileptiform transients in the first 6 h, reduced amplitude of seizures, and reduced striatal neuronal loss. In conclusion, neuroprotection with delayed, prolonged head cooling after a severe asphyxial insult in the preterm fetus was associated with potent, specific suppression of epileptiform transients in the early recovery phase but not of numbers of delayed seizures.
L Bennet; J M Dean; G Wassink; A J Gunn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-11-08
Journal Detail:
Title:  Journal of neurophysiology     Volume:  97     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-17     Completed Date:  2007-03-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  572-8     Citation Subset:  IM    
Department of Physiology, Faculty of Medicine and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
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MeSH Terms
Body Temperature / physiology*
Brain / blood supply,  physiopathology
Brain Infarction / etiology,  physiopathology,  therapy
Cerebrovascular Circulation / physiology
Corpus Striatum / blood supply,  physiopathology
Cytoprotection / physiology
Disease Models, Animal
Epilepsy / etiology*,  physiopathology,  therapy*
Fetal Hypoxia / physiopathology*
Fetus / physiopathology
Hypothermia, Induced*
Hypoxia, Brain / etiology,  physiopathology,  therapy
Hypoxia-Ischemia, Brain / complications*,  physiopathology
Nerve Degeneration / etiology,  physiopathology,  therapy
Time Factors
Treatment Outcome

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