| Differential effects of hypercapnia on expiratory phases of respiration in the piglet. | |
| | |
MedLine Citation:
|
PMID: 11311309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hypercapnia induces prolongation of expiratory time (TE) during early development. In the present study, we determined the response to steady state hypercapnia of three neural phases of the total respiratory cycle, inspiration (TI), stage 1 or passive expiration, TE-1 and stage 2 or active expiration, TE-2. Experiments were performed in decerebrate, vagotomized, spontaneously breathing piglets aged 5-10 days. Neural phases of the respiratory cycle were based on electrical activities of the thyroarytenoid (TA, laryngeal adductor) and triangularis sternii (TS, chest wall expiratory muscle) in relation to diaphragm (D) activity. We observed that hypercapnia induced prolongation of both expiratory phases. The greater prolongation of TE-1 was associated with an increase in TA activity and an increase in laryngeal resistance, which peaked early in TE-1, and then progressively decreased. These findings demonstrate that, in early postnatal life, a hypercapnia induced increase in respiratory drive is associated with centrally mediated prolongation of both phases of expiration, a greater prolongation of TE-1, and an increase in laryngeal resistance during post-inspiration. We speculate that the latter serves to optimize gas exchange by reducing large fluctuations in functional residual capacity. |
| | |
Authors:
|
I A Dreshaj; M A Haxhiu; M J Miller; J Abu-Shaweesh; R J Martin |
Related Documents
:
|
11921019 - Global fibrinolytic capacity in early respiratory distress syndrome: a pilot study. 20196389 - Early administration of the second surfactant dose in preterm infants with severe respi... 3829389 - Prospective clinical evaluation of an improved fluorescence polarization assay for pred... 21311509 - Longitudinal body composition data in exclusively breast-fed infants: a multicenter study. 12615029 - Current strategies in the prevention of respiratory syncytial virus disease. 17253569 - Postnatal thyroid hormones for respiratory distress syndrome in preterm infants. 11921019 - Global fibrinolytic capacity in early respiratory distress syndrome: a pilot study. 17508069 - Congenital epulis of the newborn: a case report. 21487249 - Analysis of nevirapine resistance in hiv-infected infants who received extended nevirap... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Respiration physiology Volume: 126 ISSN: 0034-5687 ISO Abbreviation: Respir Physiol Publication Date: 2001 May |
Date Detail:
|
Created Date: 2001-04-20 Completed Date: 2001-07-05 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0047142 Medline TA: Respir Physiol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 43-51 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, School of Medicine Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Animals, Newborn / physiology* Electromyography Female Homeostasis / physiology Hypercapnia / physiopathology* Laryngeal Muscles / physiopathology Male Respiration* Respiratory Mechanics / physiology Respiratory Muscles / physiopathology Swine Thorax Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
HL-50527/HL/NHLBI NIH HHS; HL62527/HL/NHLBI NIH HHS; U54 NS39407/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ventilatory effects of alpha2-adrenoceptor blockade in awake goats.
Next Document: Dynamics of microvascular oxygen pressure across the rest-exercise transition in rat skeletal muscle...