Document Detail


Differential effects of hypercapnia on expiratory phases of respiration in the piglet.
MedLine Citation:
PMID:  11311309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypercapnia induces prolongation of expiratory time (TE) during early development. In the present study, we determined the response to steady state hypercapnia of three neural phases of the total respiratory cycle, inspiration (TI), stage 1 or passive expiration, TE-1 and stage 2 or active expiration, TE-2. Experiments were performed in decerebrate, vagotomized, spontaneously breathing piglets aged 5-10 days. Neural phases of the respiratory cycle were based on electrical activities of the thyroarytenoid (TA, laryngeal adductor) and triangularis sternii (TS, chest wall expiratory muscle) in relation to diaphragm (D) activity. We observed that hypercapnia induced prolongation of both expiratory phases. The greater prolongation of TE-1 was associated with an increase in TA activity and an increase in laryngeal resistance, which peaked early in TE-1, and then progressively decreased. These findings demonstrate that, in early postnatal life, a hypercapnia induced increase in respiratory drive is associated with centrally mediated prolongation of both phases of expiration, a greater prolongation of TE-1, and an increase in laryngeal resistance during post-inspiration. We speculate that the latter serves to optimize gas exchange by reducing large fluctuations in functional residual capacity.
Authors:
I A Dreshaj; M A Haxhiu; M J Miller; J Abu-Shaweesh; R J Martin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Respiration physiology     Volume:  126     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-04-20     Completed Date:  2001-07-05     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  43-51     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, School of Medicine Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / physiology*
Electromyography
Female
Homeostasis / physiology
Hypercapnia / physiopathology*
Laryngeal Muscles / physiopathology
Male
Respiration*
Respiratory Mechanics / physiology
Respiratory Muscles / physiopathology
Swine
Thorax
Time Factors
Grant Support
ID/Acronym/Agency:
HL-50527/HL/NHLBI NIH HHS; HL62527/HL/NHLBI NIH HHS; U54 NS39407/NS/NINDS NIH HHS

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