Document Detail

Differential effects of high-fat and high-carbohydrate content isoenergetic meals on plasma active ghrelin concentrations in lean and obese women.
MedLine Citation:
PMID:  15326566     Owner:  NLM     Status:  MEDLINE    
AIM: To study the effect of two different isoenergetic meals, one rich in carbohydrates and one rich in fat, on plasma active ghrelin levels in lean or obese subjects. METHODS: Eight obese and eight lean women, strictly matched for age, were fed two isoenergetic meals of different composition, one rich in fat and one rich in carbohydrates (CHO), on separate days. Plasma active ghrelin levels were measured just before and at 1, 2 and 3 hours after meal consumption. RESULTS: Overall, plasma active ghrelin levels were significantly lower in the obese compared to the lean women (71.7 +/- 29.7 vs. 222.2 +/- 127.2 pmol/liter respectively, p < 0.0001). Furthermore, ghrelin levels decreased significantly by 30 % from baseline values in the lean subjects in the first hour after the CHO-rich meal (mean difference +/- SD): -66.2 +/- 49.0 pmol/liter (p = 0.03), returning to near-baseline levels by 2 hours, while no significant change was observed in the obese subjects. After the fat-rich meal, active ghrelin levels did not change significantly in either group (p > 0.05). CONCLUSIONS: A fat-rich meal does not suppress plasma active ghrelin levels in either lean or obese women. Moreover, in obese, unlike lean women, a high carbohydrate meal also fails to suppress plasma ghrelin levels, which are already quite low. This suggests that ghrelin-induced satiety mechanisms may be compromised in these subjects.
N Tentolouris; A Kokkinos; C Tsigos; D Kyriaki; J Doupis; S A Raptis; N Katsilambros
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  36     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-24     Completed Date:  2005-02-14     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  559-63     Citation Subset:  IM    
First Department of Propaedeutic Medicine, Athens University Medical School, Athens, Greece.
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MeSH Terms
Dietary Carbohydrates / administration & dosage*,  pharmacology
Dietary Fats / administration & dosage*,  pharmacology
Energy Metabolism
Middle Aged
Obesity / blood*,  metabolism
Osmolar Concentration
Peptide Hormones / blood*
Thinness / blood*,  metabolism
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 0/Ghrelin; 0/Peptide Hormones

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