Document Detail

Differential effects of fasting versus food restriction on liver thyroid hormone metabolism in rats.
MedLine Citation:
PMID:  25349245     Owner:  NLM     Status:  Publisher    
A variety of illnesses leads to profound changes in the hypothalamus-pituitary-thyroid (HPT) axis collectively known as the nonthyroidal illness syndrome (NTIS). NTIS is characterized by decreased T3 and T4 and inappropriately low TSH serum concentrations, as well as altered hepatic thyroid hormone metabolism. Spontaneous caloric restriction often occurs during illness and may contribute to NTIS, but it is currently unknown to what extent. The role of diminished food intake is often studied using experimental fasting models, but partial food restriction might be a more physiologically relevant model. In this comparative study we characterized hepatic thyroid hormone metabolism in two models for caloric restriction: 36 hours of complete fasting and 21 days of 50% food restriction. Both fasting and food restriction decreased serum T4, while after 36h fasting serum T3 also decreased. Fasting decreased hepatic T3 but not T4 concentrations, while food restriction decreased both hepatic T3 and T4. Fasting and food restriction both induced an upregulation of liver D3 expression and activity, D1 was not affected. A differential effect was seen in Mct10 mRNA expression, which was upregulated in the fasted but not in food restricted rats. Other metabolic pathways of TH, such as sulfation and UDP-glucuronidation were also differentially affected. The changes in hepatic TH concentrations were reflected by the expression of T3 responsive genes Fas and Spot14 only in the 36 hour fasted rats. In conclusion, limited food intake induced marked changes in hepatic thyroid hormone metabolism which are likely to contribute to the changes observed during NTIS.
Emmely Marije de Vries; Hermina C van Beeren; Mariette T Ackermans; Andries Kalsbeek; Eric Fliers; Anita Boelen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-27
Journal Detail:
Title:  The Journal of endocrinology     Volume:  -     ISSN:  1479-6805     ISO Abbreviation:  J. Endocrinol.     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-28     Completed Date:  -     Revised Date:  2014-10-29    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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