| Differential effects of exercise on cancer-related fatigue during and following treatment: a meta-analysis. | |
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MedLine Citation:
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PMID: 22813691 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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CONTEXT: Exercise-induced improvements in cancer-related fatigue may be moderated differentially in patients during and following treatment. These effects have not been reviewed systematically. In accordance with PRISMA guidelines, the population effect size for exercise training on cancer-related fatigue during and following treatment was estimated and the extent to which the effect is differentiated across the time course of treatment and recovery was determined. EVIDENCE ACQUISITION: Articles published before August 2011 were retrieved using Google Scholar, MEDLINE, PsycINFO, PubMed, and Web of Science databases. Seventy studies involving 4881 cancer patients during or following treatment were selected. Articles included a cancer-related fatigue outcome measured at baseline and post-intervention and randomized allocation to exercise or non-exercise comparison. From August to October 2011, Hedges' d effect sizes were computed, study quality was evaluated, and random effects models were used to estimate sampling error and population variance. EVIDENCE SYNTHESIS: Exercise significantly reduced cancer-related fatigue by a mean effect Δ (95% CI) of 0.32 (0.21, 0.43) and 0.38 (0.21, 0.54) during and following cancer treatment, respectively. During treatment, patients with lower baseline fatigue scores and higher exercise adherence realized the largest improvements. Following treatment, improvements were largest for trials with longer durations between treatment completion and exercise initiation, trials with shorter exercise program lengths, and trials using wait-list comparisons. CONCLUSIONS: Exercise reduces cancer-related fatigue among patients during and following cancer treatment. These effects are moderated differentially over the time course of treatment and recovery. Exercise has a palliative effect in patients during treatment and a recuperative effect post-treatment. |
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Authors:
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Timothy W Puetz; Matthew P Herring |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of preventive medicine Volume: 43 ISSN: 1873-2607 ISO Abbreviation: Am J Prev Med Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-07-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8704773 Medline TA: Am J Prev Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: e1-e24 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory University, Atlanta, Georgia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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