Document Detail

Differential effects of exercise on cancer-related fatigue during and following treatment: a meta-analysis.
MedLine Citation:
PMID:  22813691     Owner:  NLM     Status:  In-Data-Review    
CONTEXT: Exercise-induced improvements in cancer-related fatigue may be moderated differentially in patients during and following treatment. These effects have not been reviewed systematically. In accordance with PRISMA guidelines, the population effect size for exercise training on cancer-related fatigue during and following treatment was estimated and the extent to which the effect is differentiated across the time course of treatment and recovery was determined.
EVIDENCE ACQUISITION: Articles published before August 2011 were retrieved using Google Scholar, MEDLINE, PsycINFO, PubMed, and Web of Science databases. Seventy studies involving 4881 cancer patients during or following treatment were selected. Articles included a cancer-related fatigue outcome measured at baseline and post-intervention and randomized allocation to exercise or non-exercise comparison. From August to October 2011, Hedges' d effect sizes were computed, study quality was evaluated, and random effects models were used to estimate sampling error and population variance.
EVIDENCE SYNTHESIS: Exercise significantly reduced cancer-related fatigue by a mean effect Δ (95% CI) of 0.32 (0.21, 0.43) and 0.38 (0.21, 0.54) during and following cancer treatment, respectively. During treatment, patients with lower baseline fatigue scores and higher exercise adherence realized the largest improvements. Following treatment, improvements were largest for trials with longer durations between treatment completion and exercise initiation, trials with shorter exercise program lengths, and trials using wait-list comparisons.
CONCLUSIONS: Exercise reduces cancer-related fatigue among patients during and following cancer treatment. These effects are moderated differentially over the time course of treatment and recovery. Exercise has a palliative effect in patients during treatment and a recuperative effect post-treatment.
Timothy W Puetz; Matthew P Herring
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of preventive medicine     Volume:  43     ISSN:  1873-2607     ISO Abbreviation:  Am J Prev Med     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8704773     Medline TA:  Am J Prev Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  e1-e24     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.
Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Using international classification of diseases, 10th edition, codes to estimate abusive head trauma ...
Next Document:  Kinematic Landing Strategy Transference in Backward Rotating Gymnastic Dismounts.