Document Detail


Differential effects of emotional and physical stress on the central and peripheral secretion of neurohypophysial hormones in male rats.
MedLine Citation:
PMID:  2002757     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of various stressful conditions on the levels of oxytocin (OT) and vasopressin (VP) in plasma and cisternal cerebrospinal fluid (CSF) of male rats were investigated. Three experimental models were used: exposure to a novel environment for 5 min, immobilization for 15 min, and ether inhalation for 10 min resulting in anaesthesia. Novelty and immobilization induced a slight but significant increase in OT levels in the CSF immediately after the stress. The effect of ether was considerably more pronounced. The concentration of VP in the CSF was elevated only by ether stress. In plasma, the level of OT was increased immediately following immobilization and ether stress but not after novelty stress, whereas VP only showed a delayed response 20 min after immobilization. These results indicate a rapid preferential release of OT in the periphery in response to physical and pharmacological stress. In addition, they provide evidence that release of OT into the CSF is triggered by physical, pharmacological as well as emotional stress, while the central release of VP is rather resistant to emotional stress. The data suggest that OT is a stress hormone in the central nervous system.
Authors:
T Iványi; V M Wiegant; D de Wied
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  48     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1991  
Date Detail:
Created Date:  1991-04-12     Completed Date:  1991-04-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1309-16     Citation Subset:  IM    
Affiliation:
Department of Medical Pharmacology, Rudolf Magnus Institute, Medical Faculty, University of Utrecht, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Male
Oxytocin / blood,  cerebrospinal fluid,  secretion*
Pituitary Gland, Posterior / secretion*
Radioimmunoassay
Rats
Rats, Inbred Strains
Stress, Physiological / blood,  cerebrospinal fluid,  physiopathology*
Vasopressins / blood,  cerebrospinal fluid,  secretion*
Chemical
Reg. No./Substance:
11000-17-2/Vasopressins; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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