| Differential effects of electrolytic and chemical hypothalamic lesions on LH pulses in rats. | |
| | |
MedLine Citation:
|
PMID: 3056029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Electrolytic lesions of the arcuate nucleus were made in anesthetized adult castrated male rats. Luteinizing hormone (LH) pulse frequency averaged 2.4 pulses/h in controls but declined to a mean of 0.5 pulses/h in rats with bilateral damage to the arcuate nucleus. Because these lesions also damaged the median eminence, we tested the possibility that this disruption of LH secretion was due to coincidental damage to fibers of passage projecting to median eminence. Axon-sparing chemical lesions of the arcuate nucleus were made by intracranial injections of N-methyl-DL-aspartate (NMA) in anesthetized adult castrated rats. Mean LH pulse frequency was 2.3 and 2.5 pulses/h in control and NMA-injected rats, respectively. NMA injections destroyed arcuate neuronal cell bodies and produced a proliferation of glial cells within the nucleus. There was no apparent difference in the immunocytochemical staining intensity and distribution of luteinizing hormone-releasing hormone (LHRH) fibers in median eminence in rats receiving NMA or sham injections. These results suggest that the disruptive effects of electrolytic lesions of the arcuate nucleus on pulsatile LH secretion are a result of coincidental damage to LHRH neuronal projections to the median eminence and that neuronal cell bodies within the arcuate nucleus are not necessary for normal pulsatile LH secretion in male rats. |
| | |
Authors:
|
C L Sisk; A A Nunez; M M Thebert |
Related Documents
:
|
7354889 - Rat brain norepinephrine release during progesterone-induced lh secretion. 1170519 - Rhythms of progesterone and corticosterone in the pms-treated rat: relationship to ovul... 8940349 - An interactive physiological role of neuropeptide y and galanin in pulsatile pituitary ... 8100849 - The effect of the blockade of alpha-melanocyte-stimulating hormone on lh release in the... 6248929 - Effect of lh-rh and hypothalamic extracts on 3'-5'-cyclic-amp pituitary levels of immat... 2508979 - Effect of canatoxin on the circulating levels of gonadotropins and prolactin in rats. 438469 - Blood-brain barrier permeability in senescent rats. 3881759 - Castanospermine inhibits alpha-glucosidase activities and alters glycogen distribution ... 11290849 - Effect of neuropeptide y (npy) on oral ethanol intake in wistar, alcohol-preferring (p)... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The American journal of physiology Volume: 255 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1988 Nov |
Date Detail:
|
Created Date: 1988-12-09 Completed Date: 1988-12-09 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: E583-90 Citation Subset: IM |
Affiliation:
|
Neuroscience Program, Michigan State University, East Lansing 48824. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arcuate Nucleus / drug effects, injuries, physiology* Aspartic Acid / analogs & derivatives Electrolysis Luteinizing Hormone / secretion* Male N-Methylaspartate Periodicity Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
|
HD-21588/HD/NICHD NIH HHS; MH-37877/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
|
56-84-8/Aspartic Acid; 6384-92-5/N-Methylaspartate; 9002-67-9/Luteinizing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Altered junctional permeability between cells transformed by v-ras, v-mos, or v-src.
Next Document: Furosemide reduces insulin release by inhibition of Cl- and Ca2+ fluxes in beta-cells.