| Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-beta. | |
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MedLine Citation:
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PMID: 19860996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Some dietary fats are a risk factor for Alzheimer's disease (AD) but the mechanisms for this association are presently unknown. In the present study we showed in wild-type mice that chronic ingestion of SFA results in blood-brain barrier (BBB) dysfunction and significant delivery into the brain of plasma proteins, including apo B lipoproteins that are endogenously enriched in amyloid-beta (Abeta). Conversely, the plasma concentration of S100B was used as a marker of brain-to-blood leakage and was found to be increased two-fold because of SFA feeding. Consistent with a deterioration in BBB integrity in SFA-fed mice was a diminished cerebrovascular expression of occludin, an endothelial tight junction protein. In contrast to SFA-fed mice, chronic ingestion of MUFA or PUFA had no detrimental effect on BBB integrity. Utilising highly sensitive three-dimensional immunomicroscopy, we also showed that the cerebral distribution and co-localisation of Abeta with apo B lipoproteins in SFA-fed mice are similar to those found in amyloid precursor protein/presenilin-1 (APP/PS1) amyloid transgenic mice, an established murine model of AD. Moreover, there was a strong positive association of plasma-derived apo B lipoproteins with cerebral Abeta deposits. Collectively, the findings of the present study provide a plausible explanation of how dietary fats may influence AD risk. Ingestion of SFA could enhance peripheral delivery to the brain of circulating lipoprotein-Abeta and exacerbate the amyloidogenic cascade. |
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Authors:
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Ryusuke Takechi; Susan Galloway; Menuka M S Pallebage-Gamarallage; Cheryl L Wellington; Russell D Johnsen; Satvinder S Dhaliwal; John C L Mamo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-28 |
Journal Detail:
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Title: The British journal of nutrition Volume: 103 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-19 Completed Date: 2010-03-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 652-62 Citation Subset: IM |
Affiliation:
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Faculty of Health Science, School of Public Health, Curtin University of Technology, Bentley, WA, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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etiology*,
metabolism Amyloid beta-Protein / metabolism* Animals Apolipoprotein B-100 / blood, metabolism* Biological Markers / metabolism Blood-Brain Barrier / metabolism* Brain / metabolism* Dietary Fats / pharmacology* Disease Models, Animal Fatty Acids / metabolism, pharmacology* Fatty Acids, Unsaturated / metabolism Female Membrane Proteins / metabolism Mice Mice, Inbred C57BL Microscopy / methods Presenilin-1 Risk Factors Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Protein; 0/Apolipoprotein B-100; 0/Biological Markers; 0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Membrane Proteins; 0/Presenilin-1; 0/occludin |
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