| Differential effects of d-fenfluramine, l-fenfluramine and d-amphetamine on the microstructure of human eating behaviour. | |
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MedLine Citation:
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PMID: 11224055 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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An observational technique, demonstrated to provide reliable data under a variety of conditions, was used to evaluate the effects of d-fenfluramine, l-fenfluramine, d-amphetamine, and fenfluramine-amphetamine combinations on eating behaviour in human subjects. Following an overnight fast, subjects ate lunch from a dispenser allowing free access to a choice of ten sweet and savoury foods, of varying macronutrient composition. D-fenfluramine (30mg) and d-amphetamine (15mg) reduced food intake; l-fenfluramine (30mg) was essentially inactive. The net effects of d-fenfluramine and d-amphetamine on food intake were additive, but the behavioural mechanisms of action were different for the two drugs. D-amphetamine decreased the duration of the meal, as well as the time spent chewing or manipulating food and the number of bites, but had no effect on eating rate; by contrast, d-fenfluramine decreased the rate of eating, but had no effect on meal duration. |
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Authors:
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J. McGuirk; E. Goodall; T. Silverstone; P. Willner |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Behavioural pharmacology Volume: 2 ISSN: 1473-5849 ISO Abbreviation: Behav Pharmacol Publication Date: 1991 Apr |
Date Detail:
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Created Date: 2001-Feb-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9013016 Medline TA: Behav Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: 113-119 Citation Subset: - |
Affiliation:
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Academic Unit of Human Psychopharmacology, Medical College of St Bartholomew's Hospital, London EC1 7BE, UK Department of Psychology, City of London Polytechnic, Old Castle St, London E1 7NT, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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